Stony (Jada Pinket), Cleo (Queen Latifah), Frankie (Vivica A. Fox) and Tisean (Kimberley Elise) are four broke women in Los Angeles. When Stony's brother is shot by the police and Tisean's son is taken out of her care, the women decide to raise money by robbing a bank. Their efforts are thwarted after a police chase, and the money they obtain is in turn stolen from them by another bank robber, but the four decide to make one last attempt at a major heist.