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This book focuses on dopamine-mediated regulation of gene expression within the striatum and associated regions of the central nervous system. It is an excellent review of experimental data on interactions between neuronal systems at systemic, cellular, and molecular levels. Each of the chapters, written by the world's leading scientists, provides an understanding of anatomy, neurochemistry, and cellular and molecular effects. Such an understanding sheds light on the pathophysiology of central disorders involving the basal ganglia and leads to new approaches for the treatment of diseases such as Parkinson's disease and schizophrenia, and also addictions to psychostimulants such as cocaine and amphetamines.
This book focuses on dopamine-mediated regulation of gene expression within the striatum and associated regions of the central nervous system. It is an excellent review of experimental data on interactions between neuronal systems at systemic, cellular, and molecular levels. Each of the chapters, written by the world's leading scientists, provides an understanding of anatomy, neurochemistry, and cellular and molecular effects. Such an understanding sheds light on the pathophysiology of central disorders involving the basal ganglia and leads to new approaches for the treatment of diseases such as Parkinson's disease and schizophrenia, and also addictions to psychostimulants such as cocaine and amphetamines.
Dopamine-Mediated Gene Expression in the Neostriatum
D1 and D2 Dopamine Receptor Mediated Gene Regulation in the
Striatum, C.R. Gerfen, K.A. Keefe, and H. Steiner
Acute and Long-Term Alteration in Immediate-Early Gene Expression
by Antipsychotic Drugs: Downstream Genomic Targets, Behavioral
Correlates, and Role of D2, D3, and D4 Receptors, K.M. Merchant
Dopamine Receptor Function: An Analysis Utilizing Antisense
Knockout In Vivo, B.-C. Sun, M. Zang, A.-M. Ouagazzal, L.P. Martin,
J.M. Tepper, and I. Creese
Neurotransmitter Interactions Regulating Striatal Gene
Expression
Glutamatergic and Cholinergic Regulation of Immediate-Early Gene
and Neuropeptide Expression in the Striatum, J.Q. Wang and J.F.
McGinty
Molecular Mechanisms of Striatal Gene Regulation: A Critical Role
for Glutamate in Dopamine-Mediated Gene Induction, S.E. Hyman, R.L.
Cole, M. Schwarzchild, D. Cole, B. Hope, and C. Konradi
Persistent Alterations in Gene Expression Involved in Behavioral
Adaptations
Striatal Gene Expression Involved in Adaptive Responses to Levodopa
in Parkinsonian Models: Relevance to Long-Term Clinical Effects of
Levodopa Therapy, G.S. Robertson
Plasticity of GAD Expression in Animal Models of Movement
Disorders, M.-F. Chesselet and J.M. Delfs
Pharmacological and Molecular Regulation of the Expression of
Dopamine Receptors, B. Weiss, L.-W. Zhou, and G. Davidkova
Index
Kalpana Mechant is President and CSO at TransThera Consulting Co., Adjunct Professor of Neurology at Northwestern University Feinberg School of Medicine, Adjunct Professor of Biology at Purdue University.
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