Metabolic engineering has been developed over the past 20 years to become an important tool for the rational engineering of industrial microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of different metabolites. The overall goal is to achieve a better understanding of the metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production.

Contributors 

Part I: Emerging Methods for Redesigning Microorganisms

1. Towards Synthetic Gene Circuits with Enhancers: Biology's Multi-input Integrators; Roee Amit

2. Elementary Mode Analysis: A Useful Metabolic Pathway Analysis Tool for Reprograming Microbial Metabolic Pathways; Cong T. Trinh and R. Adam Thompson

3. Evolutionary Engineering for Industrial Microbiology; Niti Vanee, Adam B. Fisher and Stephen S. Fong

4. Monitoring Microbial Diversity of Bioreactors Using Metagenomic Approaches; Joshua T. Ellis, Ronald C. Sims and Charles D. Miller

5. Synthetic Biology Triggers New Era of Antibiotics Development; Jianfeng Wang, Zhi-Qiang Xiong, Hailin Meng, Yiguang Wang and Yong Wang

6. Cascades and Networks of Regulatory Genes That Control Antibiotic Biosynthesis; Juan F. Martín and Paloma Liras

7. Systems Analysis of Microbial Adaptations to Simultaneous Stresses; Ross P. Carlson, Olusegun J. Oshota and Reed L. Taffs

8. Metabolic Reprogramming under Microaerobic and Anaerobic Conditions in Bacteria; Yue Shan, Yong Lai and Aixin Yan

9. Tunable Promoters in Synthetic and Systems Biology; Tore Dehli, Christian Solem and Peter Ruhdal Jensen10. Analysis of Corynebacterium glutamicum Promoters and Their Applications; Jan NeSvera, Jirí Holátko and Miroslav Pátek

Part II: Metabolic Engineering for Overproducing Chemicals and Materials

11. Production of Fumaric Acid by Fermentation; Adrie J.J. Straathof and Walter M. van Gulik

12. Metabolic Engineering of Microorganisms for Vitamin C Production; Jingwen Zhou, Guocheng Du and Jian Chen

13. Molecular Mechanisms and Metabolic Engineering of Glutamate Overproduction in Corynebacterium glutamicum; Takashi Hirasawa, Jongpill Kim, Tomokazu Shirai, Chikara Furusawa and Hiroshi Shimizu

14. Microbial Metabolic Engineering for L-threonine Production; Xunyan Dong, Peter J. Quinn and Xiaoyuan Wang

15. The Production of Coenzyme Q10 in Microorganisms; Corinne P. Cluis, Dominic Pinel and Vincent J. Martin

16. Genetic Modification and Bioprocess Optimization for S-adenosyl-L-methionine biosynthesis; Xiaoqing Hu, Peter J. Quinn, Zhou Wang, Guoqiang Han and Xiaoyuan Wang

17. Manipulation of Ralstonia eutropha Carbon Storage Pathways to Produce Useful Bio-based Products; Christopher J. Brigham, Natalia Zhila, Ekaterina Shishatskaya, Tatiana G. Volova and Anthony J. Sinskey

18. Metabolic Engineering of Inducer Formation for Cellulase and Hemicellulase Gene Expression in Trichoderma reesei; Bernhard Seiboth, Silvia Herold and Christian P. Kubicek

19. Microbiologically Produced Carboxylic Acids Used as Building Blocks in Organic Synthesis; Andreas Aurich, Robert Specht, Roland A. Müller, Ulrich Stottmeister, Venelina Yovkova, Christina Otto, Martina Holz, Gerold Barth, Philipp Heretsch, Franziska A. Thomas, Dieter Sicker and Athanassios Giannis  

Index

Index