Updated edition examines the toxicological risks to parent, placenta, and fetus, providing information for improving health during key stages of reproduction and development
Section I. General1. Introduction2. Reproductive Anatomy and
Physiology3. Pharmacokinetics in Pregnancy4. Physiologically Based
Pharmacokinetic Models in Reproductive and Developmental
Toxicology5. Drugs and Chemical Contaminants in Human Breast
Milk
Section II. Toxicity Testing Models and Safety Evaluation6.
Reproductive and Developmental Safety Evaluation of New
Pharmaceutical Compounds7. Juvenile Toxicology Testing8. Postmarket
Surveillance and Regulatory Considerations in Reproductive and
Developmental Toxicology: A Food and Drug Administration
Perspective9. OECD Guidelines for In Vivo Testing of Reproductive
Toxicity10. Guidelines for Reproductive and Developmental Toxicity
Testing and Risk Assessment of Chemicals11. Validated and
Nonvalidated Mechanism-Based Methods for Testing Developmental
Toxicity12. Relevance of Animal Testing and Sensitivity of End
Points in Reproductive and Developmental Toxicity13. Embryonic
Toxic Lesions and Stem Cell Therapy14. In Vitro and Alternative
Approaches to Developmental Neurotoxicity15. In Vitro Biomarkers of
Developmental Neurotoxicity16. Using Zebrafish to Assess
Developmental Neurotoxicity17. Caenorhabditis elegans as a Model to
Assess Reproductive and Developmental Toxicity18. A Primate as an
Animal Model for Reproductive and Developmental Toxicology
Testing
Section III. Nanoparticles and Radiation19. Developmental Toxicity
of Engineered Nanomaterials20. Toxicity of Radiation: Biological
Effects of Ionizing Radiation Exposure on Reproduction
Section IV. Gases and Solvents21. Reproductive and Developmental
Toxicity of Solvents and Gases
Section V. Drugs of Abuse and Addiction, Smoking and Alcohol22.
Caffeine23. Developmental Neurotoxicity of Abused Drugs24. Effects
of Alcohol on Embryo/Fetal Development25. Cigarette Smoking and
Reproductive and Developmental Toxicity
Section VI. Pharmaceuticals and Food Additives26. Thalidomide27.
Retinoids28. Melamine and Cyanuric Acid29. Ionophores
Section VII. Metals30. Boron31. Arsenic, Cadmium, and Lead32.
Manganese33. Mercury34. Selenium
Section VIII. Pesticides, Industrial and Other Environmental
Contaminants35. Organophosphates and Carbamates36. Chlorinated
Hydrocarbons and Pyrethrins/Pyrethroids37. Herbicides and
Fungicides38. Brominated Flame Retardants39. Polychlorinated
Biphenyls, Polybrominated Biphenyls, Polychlorinated
Dibenzo-p-dioxins, and Polychlorinated Dibenzofurans40.
Reproductive Toxicity of Polycyclic Aromatic Hydrocarbons41.
Toxicity and Risk Assessment of Bisphenol A42. Ethylene Glycol43.
Perfluorooctane Sulfonate and Perfluorooctanoic Acid44.
Phthalates45. Personal Care Products and Cosmetics
Section IX. Phytotoxicants, Mycotoxins and Zootoxins46. Toxic
plants47. Fumonisins48. Aflatoxins, Ochratoxins, and Citrinin49.
Zootoxins
Section X. Special Topics50. Systems Toxicology and Predictive
Modeling of Male Developmental Toxicity51. Stem Cells in
Developmental Toxicity Testing52. Epigenetics in Reproduction and
Development53. Mitochondrial Dysfunction in Reproductive and
Developmental Toxicity54. Cell Signaling Mechanisms in
Developmental Neurotoxicity55. Neuroinflammation and Oxidative
Injury in Developmental Neurotoxicity56. Effects of Stress on
Reproductive and Developmental Biology57. Disruption of Cholesterol
Homeostasis in Developmental Neurotoxicity
Section XI. Endocrine Disruption, Mutagenicity, Carcinogenicity,
Infertility and Teratogenicity58. Endocrine Disruption59.
Developmental and Reproductive Disorders—Role of Endocrine
Disruptors in Testicular Toxicity60. Mutagenicity and
Carcinogenicity: Human Reproductive Cancer and Risk Factors61.
Environmental Pollutants and Neural Tube Defects62.
Teratogenicity63. Micro–Computed Tomography and Volumetric Imaging
in Developmental Toxicology
Section XII. Toxicologic Pathology64. Toxicologic Pathology of the
Reproductive System
Section XIII. Placental Toxicity65. The Placental Role in
Developmental Programming66. Strategies for Investigating
Hemochorial Placentation67. The Significance of ABC Transporters in
Human Placenta for the Exposure of Fetus to Xenobiotics68.
Placental Toxicity69. Placental Pathology
Section XIV. Domestic and Wildlife Species70. Reproductive and
Developmental Toxicity in Avian Species71. Endocrine Disruption in
Wildlife Species72. Teratogenesis in Livestock
Dr. Ramesh C. Gupta, Professor & Head of Toxicology Department at Murray State university, is engaged in experimental brain research in relation to Alzheimer’s disease (AD) and pesticide toxicity. He has delivered lectures in Australia, Italy, Japan, Germany, France, Switzerland, Spain, Czech Republic, China, South Korea, and Sweden. He served the panels of NIH, CDC, NIOSH, and NAS. He has >350 publications to his credit, including seven major books with Elsevier: (1) Toxicology of Organophosphate and Carbamate Compounds, (2) Veterinary Toxicology: Basic and Clinical Principles, (3) Handbook of Toxicology of Chemical Warfare Agents, (4) Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, (5) Reproductive and Developmental Toxicology, (6) Biomarkers in Toxicology and (7) Neutraceuticals. He is recipient of Murray State University's distinguished researcher award of the year-2006. He is a diplomate of American Board of Toxicology, and fellow of American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences.
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