Providing guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchers - offering a solid grounding in synthetic and physical organic chemistry, and clarifying the roles of various specialities in the development of new drugs. "Process Chemistry in the Pharmaceutical Industry" highlights new strategies for aggressive drug development programs; provides 12 case studies on agents such as inhibitors and antagonists; illustrates green chemistry and environmentally sound means of synthesizing new medicinal compounds; describes asymmetric synthesis, enantioselectivity, and phase transfer catalysis; explores crystallization and specifications for purity and rigorous new uses of physical/analytical chemistry in refining drugs; reviews the trend toward drugs with wider varieties of heterocyclic functionality, chirality, and greater complex structural features; explicates safety methods and desianalysesperiments; analyzes time-to-market schedules and consequences of acceleration of the development process in the pharmaceutical industry; clarifies the misinterpretation of process chemistry as mere scale-up work; and examines the role of automation in contemporary experimental methodology. Featuring over 1000 references, tables, and illustrations, "Process Chemistry in the Pharmaceutical Industry" is sure to find its way to the bookshelves of organic, physical, analytical, process, and medicinal chemists and biochemists; pharmacists; and upper-level undergraduate and graduate students in these disciplines.
Show moreProviding guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchers - offering a solid grounding in synthetic and physical organic chemistry, and clarifying the roles of various specialities in the development of new drugs. "Process Chemistry in the Pharmaceutical Industry" highlights new strategies for aggressive drug development programs; provides 12 case studies on agents such as inhibitors and antagonists; illustrates green chemistry and environmentally sound means of synthesizing new medicinal compounds; describes asymmetric synthesis, enantioselectivity, and phase transfer catalysis; explores crystallization and specifications for purity and rigorous new uses of physical/analytical chemistry in refining drugs; reviews the trend toward drugs with wider varieties of heterocyclic functionality, chirality, and greater complex structural features; explicates safety methods and desianalysesperiments; analyzes time-to-market schedules and consequences of acceleration of the development process in the pharmaceutical industry; clarifies the misinterpretation of process chemistry as mere scale-up work; and examines the role of automation in contemporary experimental methodology. Featuring over 1000 references, tables, and illustrations, "Process Chemistry in the Pharmaceutical Industry" is sure to find its way to the bookshelves of organic, physical, analytical, process, and medicinal chemists and biochemists; pharmacists; and upper-level undergraduate and graduate students in these disciplines.
Show moreOverview
Process Chemistry in the Pharmaceutical Industry: An
Overview, Kumar G. Gadamasetti
Strategy
Process Research and Development Strategy for Accelerated
Projects, Christopher M. Cimarusti
Case Studies
A Practical Synthesis of Ifetroban Sodium, Richard H.
Mueller
Synthesis of 5-Lipoxygenase Inhibitors, Ivan Lantos and
Richard Matsuoka
Chemistry of Vitamin D: A Challenging Field for Process
Research, Masami Okabe
A Highly Optimized and Concise Large Scale Synthesis of a Purine
Bronchodilator, Hans-Jürgen Federsel and Edib Jakupovic
Ontazolast: The Evolution of a Process, Vittorio Farina,
Karl Grozinger, Hermann Müller-Bötticher and Gregory P. Roth
Dilevalol Hydrochloride: Development of a Commercial
Process, Derek Walker
Design and Development of Practical Syntheses of LY228729, a
Potent 5HT1a Receptor Agonist, Michael J. Martinelli and David
L. Varie
Process Research and Development of CGS 19755, an NMDA
Antagonist, Peter Giannousis, John Carlson and Marius
Leimer
Route Evaluation for the Production of (R)-Levoprotiline, H.
U. Blaser, R. Gamboni, B. Pugin, G. Rihs, G. Sedelmeier, E. Schaub,
E. Schmidt, B. Schmitz, F. Spindler and Hj. Wetter
The Process Research and Development of DuPont Merck’s Cyclic
Urea Diols, A New Class of HIV Protease Inhibitors, Pat N.
Confalone and Robert E. Waltermire
Practical Enantio- and Diastereo-selective Processes for
Azetidinones, T. K. Thiruvengadam, Anantha R. Sudhakar, and
Guangzhong Wu
Synthesis of the Common Lactone Moiety of HMG-CoA Reductase
Inhibitors, Ian M. McFarlane, Christopher G. Newton and
Philippe Pitchen
Enzymatic Intervention and Phase Transfer Catalysis
Chemistry, Biocatalysis and Engineering: An Interdisciplinary
Approach to the Manufacture of the Benzodiazepine Drug Candidate LY
300164, Benjamin A. Anderson, Marvin M. Hansen, Jeffrey T.
Vicenzi and Milton J. Zmijewski
Benefits and Challenges of Applying Phase-Transfer Catalysis
Technology in the Pharmaceutical Industry, Marc E. Halpern
Asymmetric Synthesis and Enantioselectivity
Enantioselective Synthesis: The Optimum Process, John J.
Partridge and Brian L. Bray
Practical Catalysts for Asymmetric Synthesis: Ligands from
Natural Sugars for Rh-Catalyzed Asymmetric Synthesis of D- and L-
Amino Acids, Timothy A. Ayers and T. V. Rajan Babu
Chiral (Salen)Mn(III) Complexes in Asymmetric Epoxidations:
Practical Synthesis of cis-Aminoindanol and Its Application to
Enantiopure Drug Synthesis, Chris H. Senanayake and Eric N.
Jacobsen
Drug Substance Final Form and Process Safety
Chemical Development of the Drug Substance Solid Form,
Michael D. Thompson and Jean-René Authelin
The Basic Principles of Thermal Process Safety: Towards a Better
Communication Between Safety Experts and Process Chemists,
Wilfried Hoffmann
Design of Experiments and Automation
Using Factorial Experiments in the Development of Process
Chemistry, Daniel R. Pilipauskas
Laboratory Automation in Chemical Development, Martin R.
Owen and Sheila H. Dewitt
Kumar Gadamasetti
”...the book successfully achieves its goal of presenting the basic
principles and challenges associated with the discovery and
scale-up of a commercial manufacturing process of a new drug.”
— Journal of Medicinal Chemistry
”...gives a thorough overview of the challenges facing the modern
development chemists in the pharmaceutical industry. It can be
recommended to any graduates or postgraduates considering a career
in this fascinating field, and even old hands will find much
stimulating chemistry in the case studies. “
— Organic Process Research & Development
”...provides a good overview for those wanting an introduction to
the science conducted in a process research group. For experienced
process chemists, frequent descriptions of creative solutions to
difficult problems makes the book worth reading.”
— Journal of the American Chemical Society
”...recommended without reservation. It is suitable not only for
the process chemist but also for those involved in preparative work
in research in teaching, and for advanced students. It should find
a place in every chemical library.”
— Angewandte Chemie
”...presents pharmaceutical synthesis at its best in a very concise
and educational way. The wealth of references and illustrations,
and the carefully compiled subject index guarantees fast access to
further information....the lively style in which chapters are
written keeps the reader interested along the way.”
— European Journal of Pharmaceutics and Biopharmaceutics, 2000
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