Table of Contents

Preface
Contributors

1. INTRODUCTION: PAST AND FUTURE
Donald T. Stuss and Robert T. Knight
2. COGNITIVE FUNCTIONS OF THE PREFRONTAL CORTEX
Joaquín M. Fuster

SECTION I NEUROANATOM Y AND NEUROPHARMACOLOGY

Introduction to Section I: Neuroanatomy and Neuropharmacology
Helen Barbas and Trevor W. Robbins

3. PREFRONTAL PATHWAYS THAT CONTROL ATTENTION
Helen Barbas, Jamie G. Bunce, and Maria Medalla
4. FLEETING THOUGHTS: MOLECULAR VULNERABILITIES IN PREFRONTAL CORTICAL CIRCUITS
Amy F. T. Arnsten
5. OPTIMIZING THE EXECUTIVE: NEUROCHEMICAL MODULATION OF THE FRONTO-EXECUTIVE "TOOLBOX"
Trevor W. Robbins
6. THE FUNCTIONAL ROLE OF REWARD SIGNALS IN DIFFERENT PREFRONTAL AREAS
Jonathan D. Wallis and Steven W. Kennerley
7. THE MID-DORSOLATERAL PREFRONTO-PARIETAL NETWORK AND THE EPOPTIC PROCESS
Michael Petrides

SECTION II FRONTAL LOBE DEVELOPMENT

Introduction to Section II: Frontal Lobe Development
Silvia A. Bunge and Arthur W. Toga

8. POSTNATAL DEVELOPMENT OF NEURAL CIRCUITS IN THE PRIMATE PREFRONTAL CORTEX
David A. Lewis and Darlene S. Melchitzky
9. CHILDREN'S FRONTAL LOBES: NO LONGER SILENT?
Vicki Anderson and Megan Spencer-Smith
10. ADOLESCENT FRONTAL LOBES: UNDER CONSTRUCTION
Jay N. Giedd, Armin Raznahan, and Rhoshel K. Lenroot
11. ENVIRONMENTAL INFLUENCES ON PREFRONTAL DEVELOPMENT
Allyson P. Mackey, Rajeev D. S. Raizada, and Silvia A. Bunge
12. THE DEVELOPMENT OF BRAIN CONNECTIVITY SUPPORTING PREFRONTAL CORTICAL FUNCTIONS
Kai Hwang and Beatriz Luna
13. MECHANISTIC ACCOUNTS OF FRONTAL LOBE DEVELOPMENT
Yuko Munakata, Christopher H. Chatham, and Hannah R. Snyder

SECTION III SYSTEMS/MODELING

Introduction to Section III: Systems/Modelling
Earl K. Miller

14. HOW CONTEXT IMPACTS COGNITIVE AND MOTIVATIONAL CONTROL OF BEHAVIOR IN THE PRIMATE PREFRONTAL CORTEX
Masataka Watanabe
15. THE PREFRONTAL CORTEX AS A QUINTESSENTIAL "COGNITIVE-TYPE" NEURAL CIRCUIT: WORKING MEMORY AND DECISION MAKING
Xiao-Jing Wang
16. FUNCTIONAL DIVISION AMONG MONKEY PREFRONTAL AREAS IN GOAL-DIRECTED BEHAVIOR
Keiji Tanaka, Kenji Matsumoto, Farshad A. Mansouri, and Mark J. Buckley
17. ROLE OF PREFRONTAL CORTEX IN REINFORCEMENT LEARNING AND DECISION MAKING
Daeyeol Lee, Soyoun Kim, and Hyojung Seo

SECTION IV COGNITIVE NEUROSCIENCE

Introduction to Section IV: Cognitive Neuroscience
John Duncan and Etienne Koechlin

18. MOTIVATION, CONTROL, AND HUMAN PREFRONTAL EXECUTIVE FUNCTION
Etienne Koechlin
19. ADAPTIVE NEURAL CODING IN FRONTAL AND PARIETAL CORTEX
John Duncan and Earl K. Miller
20. FUNCTIONAL CONTRIBUTIONS OF THE VENTROMEDIAL PREFRONTAL CORTEX IN VALUE-BASED DECISION MAKING
John P. O'Doherty
21. NETWORK-BASED MECHANISM OF PREFRONTAL CONTROL
Katsuyuki Sakai
22. IS THERE AN INFERIOR FRONTAL CORTICAL NETWORK FOR COGNITIVE CONTROL AND INHIBITION?
Franz-Xaver Neubert, Rogier B. Mars, and Matthew F. S. Rushworth

SECTION V SOCIAL NEUROSCIENCE

Introduction to Section V: Social Neuroscience
Daniel Tranel

23. THE COGNITIVE MOTOR SYSTEM
Giacomo Rizzolatti, Leonardo Fogassi, Giuseppe Luppino, and Stefano Rozzi
24. FALSE TAGGING THEORY: TOWARD A UNITARY ACCOUNT OF PREFRONTAL CORTEX FUNCTION
Erik Asp and Daniel Tranel
25. INTENTIONAL AND INCIDENTAL SELF-CONTROL IN VENTROLATERAL PREFRONTAL CORTEX
Jessica R. Cohen, Elliot T. Berkman, and Matthew D. Lieberman
26. DYNAMIC SOCIAL JUDGMENT: THE FRONTAL LOBES AND BEYOND
Jennifer S. Beer and Jamil P. Bhanji
27. SOCIAL OUTCOME FOLLOWING EARLY-LIFE DAMAGE TO PREFRONTAL CORTEX
Steven W. Anderson and Daniel Tranel

SECTION VI NEUROPSYCHOLOGY

Introduction to Section VI: Neuropsychology
Paul W. Burgess

28. ON NEUROPSYCHOLOGICAL STUDIES OF PREFRONTAL CORTEX: THE ROBBIA APPROACH
Tim Shallice and Susan M. Gillingham
29. DECISION MAKING: EXECUTIVE FUNCTIONS MEET MOTIVATION
Lesley K. Fellows
30. A NEW ERA FOR LESION-BEHAVIOR MAPPING OF PREFRONTAL FUNCTIONS
Emmanuelle Volle, Richard Levy, and Paul W. Burgess
31. ROSTRAL PREFRONTAL CORTEX (BRODMANN AREA 10): METACOGNITION IN THE BRAIN
Paul W. Burgess and Hsuan-Chen Wu
32. BELIEFS SCULPT HUMAN SOCIAL IDENTITY
Jordan Grafman

SECTION VII AGING AND PREFRONTAL FUNCTION

Introduction to Section VII: Aging and Prefrontal Function
Patricia A. Reuter-Lorenz and Cheryl L. Grady

33. PREFRONTAL CORTEX AND SELF-INITIATED
ENCODING STRATEGY USE IN HEALTHY YOUNGER AND OLDER ADULTS
Brenda A. Kirchhoff, Staci E. Smith, and Jessica D. Luntz
34. AGING, WORKING MEMORY, AND ATTENTION CONTROL: A TALE OF TWO PROCESSING STREAMS?
Monica Fabiani and Gabriele Gratton
35. TOP-DOWN MODULATION DEFICIT IN THE AGING BRAIN: AN EMERGING THEORY OF COGNITIVE AGING
Adam Gazzaley
36. HETEROGENEITY IN FRONTAL LOBE AGING
Ulman Lindenberger, Agnieszka Z. Burzynska, and
Irene E. Nagel
37. FRONTAL LOBES AND AGING: DETERIORATION AND COMPENSATION
Roberto Cabeza and Nancy A. Dennis

SECTION VIII PSYCHIATRIC AND NEUROLOGICAL DISORDERS

Introduction to Section VIII: Psychiatric and Neurological
Disorders
Cameron S. Carter

38. PREFRONTAL CORTEX AND IMPAIRED COGNITION AND BEHAVIOR IN SCHIZOPHRENIA
Cameron S. Carter
39. SELECTIVE VULNERABILITY IN BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA
William W. Seeley
40. SELFLESS CELLS: FRONTOTEMPORAL LOBAR DEGENERATION AND EMOTIONAL FUNCTIONING
Robert W. Levenson

SECTION IX NEUROREHABILITATION

Introduction to Section IX: Neurorehabilitation
Ian H. Robertson and Mark D'Esposito

41. TRAINING OF AGING FRONTAL LOBES: POSSIBILITIES AND CONSTRAINTS
Lars Nyberg and Lars Bäckman
42. PHYSICAL ACTIVITY EFFECTS ON BRAIN AND BEHAVIOR
Ruchika Shaurya Prakash, Michelle W. Voss, and Arthur F. Kramer
43. REMEDIATING FRONTAL LOBE DYSFUNCTION: FROM BENCH TO BEDSIDE
Mark D'Esposito and Anthony J.-W. Chen
44. ATTENTION AND AROUSAL IN NEUROREHABILITATION
Ian H. Robertson and Brian Levine

SECTION X OVERVIEW

45. NEURAL OSCILLATIONS AND PREFRONTAL CORTEX
Robert T. Knight

Index

About the Author

Donald T. Stuss, Ph.D., C. Psych., ABPP-CN, Order of Ontario, FRSC, FCAHS, is the founding (2011) President and Scientific Director of the Ontario Brain Institute; a Senior Scientist at the Rotman Research Institute of Baycrest Centre; University of Toronto Professor of Medicine (Neurology and Rehabilitation Science) and Psychology; founding Director of the Rotman Research Institute at Baycrest 1989 - 2008. His research focuses on understanding and
treating the cognitive functions and personality changes associated with the frontal lobes as they occur after stroke, normal elderly, and in those with traumatic brain injury or dementia. He has one co-authored book,
and four co-edited books; over 190 publications and 48 chapters; and presented over 250 invited scientific lectures and workshops. His publications have been cited over 13,000 times, with an H index of 58.

Robert T. Knight, MD, received a degree in Physics from the Illinois Institute of Technology, an MD from Northwestern University Medical School, obtained Neurology training at UCSD and did post-doctoral work at the Salk Institute for Biological Studies. He was a faculty member in the Department of Neurology at UC Davis School of Medicine from 1980-1998 and moved to UC Berkeley in 1998 serving as Director of the Helen Wills Neuroscience Institute from 2001 until 2011. His
laboratory utilizes electrophysiological techniques in neurological and neurosurgical patients to delineate the role of prefrontal cortex in human cognitive. His laboratory also records electrocorticographic activity from
neurosurgical patients with subdural electrodes to delineate cortical mechanisms of behavior as well as for development of neural prosthesis for motor and language restoration.. He founded the UC Berkeley-UCSF Center for Neural Engineering and Prosthesis in 2010. Dr. Knight received the Jacob Javits Award from the National Institute of Neurological Disorders and Stroke for distinguished contributions to understanding neurological disorders, the IBM Cognitive Computing Award and the Humboldt
Prize in Neurobiology. His H index is 67.

Reviews

"Principles of Frontal Lobe Function by Don Stuss and Bob Knight delivers on its title, integrating contemporary cognitive neuroscience with frontal lobe development, neurochemistry, social cognition, anatomy, and neuropsychology. Principles provides a comprehensive, integrated view of frontal lobe function across the human life span. Principles is a terrific source of information to guide both the novice and the authority looking
for an up-to-date summary of our understanding of the frontal lobes."
-- Jeffrey L. Cummings, M.D., Sc.D., Director, Lou Ruvo Center for Brain Health, Camille and Larry Ruvo Chair for Brain Health, Cleveland Clinic, 888 W Bonneville Ave, Las Vegas, NV
"More than 150 years after Phineas Gage, the frontal lobes continue to bewilder. Will a unified principle eventually emerge, or is the current functional mosaic irreducible? If the latter, will the final canvas resemble a Pollock or a Mondrian? This timely volume, buiding upon the justified fame of its first edition, takes the ongoing exploration of prefrontal cortex to new levels of sophistication."
-- M-Marsel Mesulam, MD, Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Chicago, IL
"The frontal cortex comprises about one third of the human cerebral cortex, and is double the size of our closest ape relatives. This highly evolved portion of our brain is anatomically and physiologically complex and it mediates a variety of important neuropsychological functions. Frontal dysfunction, which can be caused by many diseases, has devastating consequences and thus, detailed and current information about frontal lobe function and dysfunction is
critical knowledge for the clinician and basic scientist. This Second Edition is a well written, multi-authored classic text that provides the reader with this important knowledge."
-- Kenneth M. Heilman MD, The James E. Rooks Jr. Distinguished Professor, Department of Neurology, University of Florida College of Medicine, Gainesville, FL
"Ten years ago, Stuss and Knight edited the definitive reference on prefrontal function. This new, eagerly awaited successor is chock full of the latest findings on prefrontal anatomy, physiology, and function. The prefrontal roles in social behavior, development, executive function, attention, and memory are all nicely covered by the experts in their respective areas. Best of all, the contributors do not merely review the new literature, but clearly express
their own points of view, providing the reader with a feast of fresh new ideas."
-- Robert Desimone, PhD, Director, McGovern Institute for Brain Research at MIT, Doris and Don Berkey Professor of Neuroscience, Massachusetts Institute of Technology, Cambridge, MA
"Principles of Frontal Lobe Function by Stuss and Knight reflects the continuing evolution of our understanding of frontal lobe, and incorporates the wealth of new knowledge that has been made possible by technological advances in cellular and molecular neuroscience, functional and structural imaging, neurochemistry and microcircuitry. This second edition captures the broadened perspective of frontal lobe function to include constructs that far exceed
our traditional focus on executive functions... This volume should be required for students, clinical and basic neuroscientists, and anyone with an interest in brain function. The comprehensive approach and
integration of such a broad body of knowledge sets a model and a standard by which other volumes about brain function should be measured."
-- Robert A. Bornstein, PhD, Vice Dean for Academic Affairs, The Ohio State University College of Medicine, Columbus, Ohio
"This book with 45 chapters organized into nine sections has so much more information than what was contained in the 34 chapters of the first edition published in 2002...New methods of observing and imaging the structural and functional parts of the frontal lobe of the human brain and monkey brains has led to gathering a massive amount of new data, which in turn has increased the knowledge base and insight currently available on this part of the human brain."
-- Biz India
"This is a marvelously updated edition of a classic reference on the frontal lobes. Anyone interested in the brain and behavior should be referring to this book. I highly recommend it!" -- Michael Joel Schrift, DO, MA, Doody's
"With some 90 contributors, including section editors and coeditors, the range of topics covered in this tome is vast.... New methods of observing and imaging the structural and functional parts of the frontal lobe of the human brain and monkey brains has led to gathering a massive amount of new data, which in turn has increased the knowledge base and insight currently available on this part of the human brain. The new research uncovered in this book can be
helpful to specialists involved in treating patients with frontal lobe dysfunction, including neurological and psychiatric disorders such as multiple sclerosis, obsessive-compulsive behavior, traumatic
brain injury, and white matter disease." -- BizIndia