Primer on Multiple Sclerosis, 2nd Edition is an updated reference manual for the practicing clinician. It covers the range of information needed to treat persons with MS, beginning with basic science and immunopathology, thorough differential diagnosis, symptom management and disease modifying therapies. This essential book also includes material covering new and experimental strategies as well as a review of commonly used complementary and alternative modalities
that are used by persons with MS.Multiple Sclerosis (MS) is the most common demyelinating disease of the CNS and the third most common cause of disability among young adults. The complex management
issues that are often present in the care of individuals with MS may demand the participation of health care professionals from a variety of disciplines, although the team is usually led by a neurologist. It is therefore essential for the neurologist to have a thorough grounding in the basic science and clinical phenomenology of MS.In this second edition of Primer on Multiple Sclerosis, the latest updates on therapeutics are provided, including new medications that have
been FDA- approved since the first edition. Includes new diagnostic criteria, as well as any advances made in current diagnostic techniques, e.g. new imaging metrics. Important new information in the
basic sciences and pathophysiology of MS is provided as well as newer epidemiologic studies. Treatment algorithms for common symptoms will be expanded, as well as any new guidelines for switching medications for Disease Modifying treatment "failures". The chapter on alternative and complimentary therapies discusses new research on CCSVI. The chapter on legal issues includes information on the putative effect of the Affordable Health Care Act on access to neurologic care and treatments.
Finally, there is expanded discussion of progressive forms of MS both from a basic science and treatment perspective.
Primer on Multiple Sclerosis, 2nd Edition is an updated reference manual for the practicing clinician. It covers the range of information needed to treat persons with MS, beginning with basic science and immunopathology, thorough differential diagnosis, symptom management and disease modifying therapies. This essential book also includes material covering new and experimental strategies as well as a review of commonly used complementary and alternative modalities
that are used by persons with MS.Multiple Sclerosis (MS) is the most common demyelinating disease of the CNS and the third most common cause of disability among young adults. The complex management
issues that are often present in the care of individuals with MS may demand the participation of health care professionals from a variety of disciplines, although the team is usually led by a neurologist. It is therefore essential for the neurologist to have a thorough grounding in the basic science and clinical phenomenology of MS.In this second edition of Primer on Multiple Sclerosis, the latest updates on therapeutics are provided, including new medications that have
been FDA- approved since the first edition. Includes new diagnostic criteria, as well as any advances made in current diagnostic techniques, e.g. new imaging metrics. Important new information in the
basic sciences and pathophysiology of MS is provided as well as newer epidemiologic studies. Treatment algorithms for common symptoms will be expanded, as well as any new guidelines for switching medications for Disease Modifying treatment "failures". The chapter on alternative and complimentary therapies discusses new research on CCSVI. The chapter on legal issues includes information on the putative effect of the Affordable Health Care Act on access to neurologic care and treatments.
Finally, there is expanded discussion of progressive forms of MS both from a basic science and treatment perspective.
Part 1: Historical Background
Chapter 1: The History of Multiple Sclerosis: From the Age of
Description to the Age of Therapy
T. Jock Murray
Part 2: Basic Science
Chapter 2: Genetics and Epidemiology in Multiple Sclerosis
Gabriele C. DeLuca, Richard L. Yates and A. Dessa Sadovnick
Chapter 3: Neurophysiology of Multiple Sclerosis
Jefferson C. Slimp
Chapter 4: Immunology of Multiple Sclerosis
Laura Piccio and Anne H. Cross
Chapter 5: Taking a Microscopic Look at Multiple Sclerosis
Yong Guo and Claudia F. Lucchinetti
Part 3: Diagnosis and Prognosis
Chapter 6: Diagnosis of Multiple Sclerosis
Loren A. Rolak
Chapter 7: Neuroimaging in Multiple Sclerosis
Megan Esch & Nancy L. Sicotte
Chapter 8: Cerebrospinal Fluid Profile Supporting a Clinical
Definite Multiple Sclerosis Diagnosis
Mark Freedman and Mohammed Abdoli
Chapter 9: Evoked Potentials
Marc R. Nuwer
Chapter 10: Temporal and Clinical Course of Multiple Sclerosis
Erica Grazioli, Cornelia Mihai, and Bianca Weinstock-Guttman
Chapter 11: Outcome Measures in Multiple Sclerosis
Robert M. Herndon
Part 4: Clinical Manifestations
Chapter 12: Neuro-Ophthalmologic Manifestations of Multiple
Sclerosis
Shin C. Beh, Elliot M. Frohman, and Teresa Frohman
Chapter 13: Cerebellar and Brainstem Dysfunction in Multiple
Sclerosis
Angeli S. Mayadev and George H. Kraft
Chapter 14: Disorders of Mobility in Multiple Sclerosis
Scott Campea and Jodie K. Haselkorn
Chapter 15: Management of Urinary and Bowel Dysfunction in Patients
with Multiple Sclerosis
Ja-Hong Kim and Judy M. Choi
Chapter 16: Assessment and Treatment of Sexual Dysfunction in
Multiple Sclerosis
Frederick W. Foley
Chapter 17: Gender and Reproductive Issues in Multiple
Sclerosis
Rhonda Voskuhl and Barbara S. Giesser
Chapter 18: Cognitive Impairment and Mood Disturbances
Nicholas G. LaRocca
Chapter 19: Multiple Sclerosis and Pain
Norman S. Namerow
Chapter 20: Fatigue in Multiple Sclerosis
Vikram Bhise, Leigh Charvet, and Lauren Krupp
Chapter 21: Sleep Disorders in Multiple Sclerosis
Tiffany J. Braley and Alon Y. Avidan
Chapter 22: Pediatric Multiple Sclerosis
J.M. Tillema, J. Graves, L.A. Benson, G.S. Aaen, A. Belman, J.
Parrish, B. Weinstock-Guttman, L. Krupp, T. Chitnis, and E.
Waubant,
Part 5: Therapeutics
Chapter 23: Neuromyelitis Optica Spectrum Disorders
Dean M. Wingerchuk
Chapter 24: Multiple Sclerosis Nursing
Kirstin Nygren and Gail Hartley
Chapter 25: Immunomodulatory Agents for Relapsing-Remitting
Multiple Sclerosis
Jessica F. Robb and Lawrence M. Samkoff
Chapter 26: Immunosuppressive and Novel Therapies
Barbara S. Giesser
Chapter 27: Complementary and Alternative Medicine in Multiple
Sclerosis
Allen C. Bowling
Part 6: Psychosocial Issues
Chapter 28: Living with Multiple Sclerosis: The Psychosocial
Challenges for Patients and Their Families Rosalind C. Kalb
Chapter 29: Employment and Career Development Considerations
Steven W. Nissen and Phillip D. Rumrill, Jr.
Chapter 30: Legal Planning Issues
Laura D. Cooper, Esq.
Part 7: Research
Chapter 31: Issues in the Design and Interpretation of Multiple
Sclerosis Clinical Trials
Stephen Krieger, Ilana Katz Sand, Svenja Oynhausen, and Aaron
Miller
Chapter 32: Basic Science in Multiple Sclerosis: Progress and
Promise
Wendy Gilmore and Leslie P. Weiner
Barbara S. Giesser, MD
Clinical Director, UCLA MS Program
David Geffen School of Medicine, UCLA
Los Angeles, CA
"This new volume provides a highly accessible summary of a most
dynamic area of medicine, featuring updates by many leading
authorities in the field. The new edition of Dr. Geisser's primer
has great practical value for all clinicians who care for people
with multiple sclerosis." --- Stephen L. Hauser, MD Professor &
Chair, Department of Neurology, University of California, San
Francisco, CA
"Dr. Barbara S. Giesser's second edition of Primer On Multiple
Sclerosis is an impressive and highly successful comprehensive
review and synthesis of the huge scientific literature concerning
multiple sclerosis. In reading it, one will come to appreciate the
remarkable progress we have made and, yet, how much further we
still have to go to eliminate this disease from the myriad of
sufferings mankind is faced with. I know of no better resource
to
educate sophisticated patients, clinicians, researchers and health
policy advocates about MS." --Timothy Vollmer, MD, Co-Director,
RMMSC at Anschutz Medical Director, RMMSC, Director, Neurology
Clinical Research,
Professor, Department of Neurology, Aurora, CO
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