Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease provides an overview of the basic principles of free radical formation. The text delves into free radical formation in molecular biology and its effect on subcellular damage, as well as the role of antioxidant reserves as a protective mechanism. Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.

List of Contributors, ix Special Recognition, xiii Foreword, xv Preface, xvii Section 1: Introduction 1 Introduction to Free Radicals, Inflammation, and Recycling, 3 Donald Armstrong 2 Diagnostic Imaging and Differential Diagnosis, 11 Robert D. Stratton Section 2: Clinical Correlations on Acute and Chronic Diseases 3 Free Radicals: Their Role in Brain Function and Dysfunction, 23 Natan Gadoth 4 Mediators of Neuroinflammation, 39 Rajiv Tikamdas, Ping Zhang, and Bin Liu 5 Oxidative and Nitrative Stress in Schizophrenia, 57 Anna Dietrich-Muszalska 6 The Effects of Hypoxia, Hyperoxia, and Oxygen Fluctuations on Oxidative Signaling in the Preterm Infant and on Retinopathy of Prematurity, 77 M. Elizabeth Hartnett 7 Oxidative Damage in the Retina, 93 Robert D. Stratton 8 The Role of Oxidative Stress in Hearing Loss, 115 Colleen G. Le Prell and Josef M. Miller 9 Disorders of Children, 133 Hirokazu Tsukahara and Masato Yashiro 10 Oxidative Stress in Oral Cavity: Interplay between Reactive Oxygen Species and Antioxidants in Health, Inflammation, and Cancer, 155 Maurizio Battino, Maria Greabu and Bogdan Calenic 11 Oxidative Stress and the Skin, 167 Christina L. Mitchell 12 Oxidative Stress in Osteoarticular Diseases, 183 María José Alcaraz, Sergio Portal-Núñez, Juan A. Ardura and Pedro Esbrit 13 Gene Therapy to Reduce Joint Inflammation in Horses, 193 Patrick Colahan, Rachael Watson, and Steve Ghivizzani 14 Muscle and Oxidative Stress, 205 Reza Ghiasvand and Mitra Hariri 15 Role of Oxidants and Antioxidants in Male Reproduction, 221 Ashok Agarwal, Hanna Tadros, Aaron Panicker and Eva Tvrdá 16 Role of Oxidants and Antioxidants in Female Reproduction, 253 Ashok Agarwal, Hanna Tadros and Eva Tvrdá 17 Reactive Oxygen Species, Oxidative Stress, and Cardiovascular Diseases, 281 Fatemeh Sharifpanah and Heinrich Sauer 18 Oxidative Stress and Antioxidant Imbalance: Respiratory Disorders, 307 Surinder K. Jindal 19 Oxidative Stress and Type 1 Diabetes, 319 Chao Liu, Clayton E. Mathews, and Jing Chen 20 Metabolic Syndrome, Inflammation, and Reactive Oxygen Species in Children and Adults, 329 William E. Winter and Janet H. Silverstein 21 Oxidative Stress in Chronic Pancreatitis, 339 Shweta Singh and Bechan Sharma 22 Wound Healing and Hyperbaric Oxygen Therapy Physiology: Oxidative Damage and Antioxidant Imbalance, 347 James R. Wilcox and D. Scott Covington 23 Radiobiology and Radiotherapy, 357 Justin Wray and Judith Lightsey 24 Chemotherapy-Mediated Pain and Peripheral Neuropathy: Impact of Oxidative Stress and Inflammation, 367 Hassan A.N. El-Fawal, Robert Rembisz, Ryyan Alobaidi, and Shaker A. Mousa 25 Grape Polyphenol-rich Products with Antioxidant and Anti-inflammatory Properties, 389 Eduarda Fernandes, Marisa Freitas, Renan C. Chisté, Elena Falqué, and Herminia Domínguez 26 Isotonic Oligomeric Proanthocyanidins, 403 Hanbo Hu and Donald Armstrong 27 Superoxide Dismutase Mimics and Other Redox-active Therapeutics, 415 Ines Batinic-Haberle and Artak Tovmasyan 28 Herbal Medicine: Past, Present, and Future with Emphasis on the Use of Some Common Species, 471 Aneela Afzal and Mohammad Afzal 29 Ayurvedic Perspective on Oxidative Stress Management, 483 Priyanka M. Jadhav 30 Clinical Trials and Antioxidant Outcomes, 493 Carlos Palacio and Arshag D. Mooradian 31 Statistical Approaches to Make Decisions in Clinical Experiments, 507 Albert Vexler and Xiwei Chen Index, 561