Paperback : £51.91
Praise for the first edition:
... superb, beautifully written and organized work that takes an engineering approach to systems biology. Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly without interfering with the main text. He starts with a mathematical description of transcriptional activation and then describes some basic transcription-network motifs (patterns) that can be combined to form larger networks. - Nature
[This text deserves] serious attention from any quantitative scientist who hopes to learn about modern biology ... It assumes no prior knowledge of or even interest in biology ... One final aspect that must be mentioned is the wonderful set of exercises that accompany each chapter. ... Alon's book should become a standard part of the training of graduate students. - Physics Today
Written for students and researchers, the second edition of this best-selling textbook continues to offer a clear presentation of design principles that govern the structure and behavior of biological systems. It highlights simple, recurring circuit elements that make up the regulation of cells and tissues. Rigorously classroom-tested, this edition includes new chapters on exciting advances made in the last decade.
Features:
The book website including course videos can be found here: https://www.weizmann.ac.il/mcb/UriAlon/introduction-systems-biology-design-principles-biological-circuits.
Show morePraise for the first edition:
... superb, beautifully written and organized work that takes an engineering approach to systems biology. Alon provides nicely written appendices to explain the basic mathematical and biological concepts clearly and succinctly without interfering with the main text. He starts with a mathematical description of transcriptional activation and then describes some basic transcription-network motifs (patterns) that can be combined to form larger networks. - Nature
[This text deserves] serious attention from any quantitative scientist who hopes to learn about modern biology ... It assumes no prior knowledge of or even interest in biology ... One final aspect that must be mentioned is the wonderful set of exercises that accompany each chapter. ... Alon's book should become a standard part of the training of graduate students. - Physics Today
Written for students and researchers, the second edition of this best-selling textbook continues to offer a clear presentation of design principles that govern the structure and behavior of biological systems. It highlights simple, recurring circuit elements that make up the regulation of cells and tissues. Rigorously classroom-tested, this edition includes new chapters on exciting advances made in the last decade.
Features:
The book website including course videos can be found here: https://www.weizmann.ac.il/mcb/UriAlon/introduction-systems-biology-design-principles-biological-circuits.
Show morePart 1: Network Motifs. 1. Transcription Networks: Basic Concepts. 2. Autoregulation: A Network Motif. 3. The Feedforward Loop Network Motif. 4. Temporal Programs and the Global Structure of Transcription Networks. 5. Positive Feedback, Bistability, and Memory. 6. How to Build a Biological Oscillator. Part 2: Robustness. 7. Kinetic Proofreading and Conformational Proofreading. 8. Robust Signaling by Bifunctional Components. 9. Robustness and Bacterial Chemotaxis. 10. Fold-Change Detection. 11. Dynamical Compensation and Mutant Resistance in Tissues. 12. Robust Spatial Patterning in Development. Part 3: Optimality. 13. Optimal Gene Circuit Design. 14. Multi-Objective Optimality in Biology. 15. Modularity. Appendix A: The Input Functions of Genes: Michaelis-Menten and Hill Equations. Appendix B: Multi-Dimensional Input Functions. Appendix C: Graph Properties of Transcription Networks. Appendix D. Noise in Gene Expression.
Uri Alon is the Abisch-Frenkel professor of systems biology at the Weizmann Institute of Science; https://www.weizmann.ac.il/mcb/UriAlon/homepage
"Systems biology is based on the idea that engineered and evolved
systems share common principles. Here, Alon (Weizmann Inst. of
Science, Rehovot) elucidates three of the major principles... This
book is a compendium of many different experiments. Together, they
show that biological systems do obey these design principles." --P.
Cull, Oregon State University, CHOICE connect (57:5, Jan 2020)"A
very good book. Very well written, everything is clearly
illustrated and presented. It makes a tough subject easy to
follow." --Radu Angelescu, Senior Programmer at Ubisoft"Alon’s book
is the ideal counterargument to the idea that organisms are
inherently human-opaque: it directly demonstrates the
human-understandable structures which comprise real biological
systems." --LessWrong.comPraise for the First Edition"[This text
deserves] serious attention from any quantitative scientist or
physicist who hopes to learn about modern biology. … the author
succeeds in explaining in an intellectually exciting way what the
cell does and what degrees of freedom enable it to function. … He
draws the detailed strands together into an appealing and inspiring
overview of biology. … Alon’s book should become a standard part of
the training of graduate students in biological physics… ."
—Nigel Goldenfeld, University of Illinois at Urbana-Champaign,
Physics Today, June 2007
"…a superb, beautifully written and organized work that takes an
engineering approach to systems biology. … He does an excellent job
of explaining and motivating a useful toolbox of engineering models
and methods using network-based controls. … a valuable and
non-overlapping addition to a systems-biology curriculum."
—Eric Werner, University of Oxford, Nature, Vol. 446, No. 29, March
2007
"I read Uri Alon’s elegant book almost without stopping for breath.
He perceives and explains so many simple regularities, so clearly,
that the novice reading this book can move on immediately to
research literature, armed with a grasp of the many connections
between diverse phenomena."
—Philip Nelson, University of Pennsylvania, Philadelphia, USA
"… Beyond simply recounting recent results, Alon boldly articulates
the basic principles underlying biological circuitry at different
levels and shows how powerful they can be in understanding the
complexity of living cells. For anyone who wants to understand how
a living cell works, but thought they never would, this book is
essential."
—Michael B. Elowitz, California Institute of Technology, Pasadena,
USA
"Uri Alon offers a highly original perspective on systems biology,
emphasizing the function of certain simple networks that appear as
ubiquitous building blocks of living matter. …"
—Boris Shraiman, University of California, Santa Barbara, USA
"This is a remarkable book that introduces not only a field but a
way of thinking. Uri Alon describes in an elegant, simple way how
principles such as stability, robustness and optimal design can be
used to analyze and understand the evolution and behavior of living
organisms. Alon’s clear intuitive language and helpful examples
offer — even to a mathematically naive reader — deep mathematical
insights into biology. The community has been waiting for this
book; it was worth the wait."
—Galit Lahav, Harvard Medical School, Boston, Massachusetts, USA
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