Table of Contents

Consensus Definitions, Fundamental Concepts, and a Standardized Approach to Applied Biomaterials Sciences. Biology, Biomechanics, Biomaterial Interactions: Wound Healing Biology. Cutaneous Wound Pathobiology: Raison d’etre for Tissue Engineering. Osseous Wound Healing. Biology, Biomechanics, Biomaterial Interactions: Cellular Mechanics. Cell and Tissue Mechanobiology. Biology, Biomechanics, Biomaterial Interactions: Materials–Host Interactions. Cell–Material Interactions: Fundamental Design Issues for Tissue Engineering and Clinical Considerations. Host Response to Biomaterials. Protein Adsorption at the Biomaterial–Tissue Interface. Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property: Standardized Materials Testing. In Vitro Testing of Biomaterials. Assessment of Biomaterials: Standardized In Vivo Testing. Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property: Statistics. Basic Principles of Statistics: Considerations for Biomaterials Engineers. Therapy Development, Animal Testing, and Regulatory Issues. Fundamentals of Patenting for the Biomaterials Scientist. Biomaterials Compositions. Proteins and Amino Acid–Derived Polymers. Three-Dimensional Fibrin Constructs in Tissue Engineering. Biomedical Polyurethanes. Polymers Derived from l-Tyrosine. Poly(propylene Fumarate). Complex Polysaccharides: Chitosan and Alginate. Collagen: A Natural Biomaterial for Tissue Engineering. Polyphosphazenes. Biologically Active Glasses. Silk-Based Biomaterials: Biology, Properties, and Clinical Applications. Calcium-Based Bioceramics: Biology, Properties, and Clinical Applications. Biomaterials Applications. Tissue Engineering of Skin. Polymeric Biomaterials for Drug and Nucleic Acid Delivery. Orthopedic Prostheses and Joint Implants. Bone and Biomaterials. Functional Regeneration of Synovial Joints In Vivo: The Role of Biomaterials and Scaffold Design. Tissue Engineering, Biomaterials, and the Nervous System. Ligaments, Biomaterials, and Tissue-Engineering Opportunities. Cardiovascular Tissue Engineering and Biomaterials. Index.

About the Author

Dr. Jeffrey O. Hollinger graduated from Hofstra University in 1969 and received a dental degree and PhD from the University of Maryland in 1973 and 1981, respectively. In addition, he completed a dental residency program and craniofacial fellowship in the U.S. Army Dental Corps. Since 2000, Dr. Hollinger has been a tenured professor at Carnegie Mellon University (CMU) in the departments of biomedical engineering and biological sciences. He is the director of the Bone Tissue Engineering Center at CMU. From 1993 to 2000, he was a tenured professor at the Oregon Health Sciences University in the departments of surgery and developmental biology, and he directed the Northwest Wound Healing Center. In 1993 Dr. Hollinger retired from the U.S. Army as a colonel after serving 20 years of active duty. During that period, he was the director of the Army's Bone Program, as well as the director of the Department of Physiology and Biochemistry at the U.S. Army Institute of Dental Research at the Walter Reed Army Medical Center in Washington, DC. He has over 35 years of experience in bone regeneration using biological factors, biomaterials, and preclinical animal models. Dr. Hollinger has received numerous federal grants as the principal investigator (NIH, NSF, DoD, and NIST) focusing on applied and fundamental sciences for bone regeneration and is engaged with several industrial groups emphasizing bone regenerative therapeutics, as well as serving on corporate boards. Dr. Hollinger has several patents and has licensed technology developed in his lab. He received the prestigious Clemson Award in biomaterials in 2008. He has over 250 peer-reviewed publications, abstracts, book chapters, and books.