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Hurst's the Heart, 14th ­Edition
Two Volume Set

Rating
Format
Mixed media product, 2208 pages
Published
United States, 16 May 2017


Contributorsxi


Prefacexxv


Abbreviationsxxvii



Volume One


SECTION 1


Cardiovascular Disease: Past, Present, and Future


1.A History of the Cardiac Diseases, and


the Development of Cardiovascular Medicine


as a Specialty3


Robert A. Harrington, Mark E. Silverman, and Charles F. Wooley


2.The Global Burden of Cardiovascular Diseases19


Catherine P. Benziger, Andrew E. Moran, and Gregory A. Roth


3.Assessing and Improving the Quality of Care


in Cardiovascular Medicine52


Yashashwi Pokharel and John A. Spertus



SECTION 2


Foundations of Cardiovascular Medicine


4.Functional Anatomy of the Heart67


Joseph F. Malouf, Joseph J. Maleszewski, A. Jamil Tajik, and James B. Seward


5.Normal Physiology of the


Cardiovascular System101


Rodrigo Fernandez-Jimenez, Brian D. Hoit, Richard A. Walsh, Valentin Fuster, and Borja Ibanez


6.Molecular and Cellular Biology of the Heart125


Roger J. Hajjar, Kiyotake Ishikawa, and Thomas Thum


7.Biology of the Vessel Wall144


Hillary Johnston-Cox, Valentin Fuster, and Jason C. Kovacic


8.Molecular and Cellular Development


of the Heart161


Miguel Torres and Silvia Martín-Puig


9.Genetic Basis of Cardiovascular Disease174


Eloisa Arbustini, Valentina Favalli, Nupoor Narula, Eliana Disabella, and Maurizia Grasso


v


10.Stem Cells and the Cardiovascular System205


Karim Sallam and Joseph C. Wu



SECTION 3


Evaluation of the Patient


11.The History, Physical Examination, and


Cardiac Auscultation225


William R. Miranda and Rick A. Nishimura


12.Surface Electrocardiography252


Antoni Bayés de Luna, Diego Goldwasser, Miquel Fiol, and Antoni Bayés-Genis


13.Electrocardiographic Exercise Testing318


Gregory S. Thomas and Myrvin H. Ellestad


14.Cardiac Radiography335


Geoffrey D. Rubin


15.Echocardiography353


Thomas H. Marwick, Anthony N. DeMaria, Daniel G. Blanchard, and William A. Zoghbi


16.Magnetic Resonance Imaging of the Heart433


W. Gregory Hundley, Christopher M. Kramer, and Javier Sanz


17.Computed Tomography of the Heart469


Amir Ahmadi, Jagat Narula, and Jonathon Leipsic


18.Nuclear Cardiology499


Daniel S. Berman, Rory Hachamovitch, Leslee J. Shaw, Sean W. Hayes, Piotr J. Slomka, Guido Germano,


and Jagat Narula


19.Positron Emission Tomography


in Heart Disease553


K. Lance Gould, Heinrich Schelbert, and Jagat Narula


20.Cardiac Catheterization, Cardiac Angiography, and Coronary Blood Flow and Pressure


Measurements606


Morton J. Kern and Arnold H. Seto


21.Coronary Intravascular Imaging657


Christos V. Bourantas, Yoshinobu Onuma, Renu Virmani, Jagat Narula, and Patrick W. Serruys


22.Magnetic Resonance Imaging


and Computed Tomography of the


Vascular System686


Marc R. Dweck, Michelle C. Williams, Prakash Krishnan, Valentin Fuster, Jagat Narula, and Zahi A. Fayad



viContents


SECTION 4


Systemic Arterial Hypertension


23.Epidemiology of Hypertension703


Nathan D. Wong and Stanley S. Franklin


24.Pathophysiology of Hypertension720


John E. Hall, Joey P. Granger, Daniel W. Jones, and Michael E. Hall


25.Diagnosis and Treatment of Hypertension751


Lawrence R. Krakoff



SECTION 5


Metabolic Disorders and Cardiovascular Disease


26.The Metabolic Syndrome767


Michael A. Via and Jeffrey I. Mechanick


27.Obesity and Cardiovascular Disease776


W. Timothy Garvey and Jeffrey I. Mechanick


28.Diabetes and Cardiovascular Disease789


Michael E. Farkouh, Elliot J. Rayfield, and Valentin Fuster


29.Hyperlipidemia817


Robert S. Rosenson and Scott M. Grundy



SECTION 6


Cigarette Smoking and Cardiovascular Diseases


30.Epidemiology of Smoking and Pathophysiology


of Cardiovascular Damage849


Sunil K. Agarwal, Petra Maslov, Jagat Narula, and Valentin Fuster


31.Preventing and Mitigating Smoking-Related


Heart Disease860


Sara Kalkhoran and Stanton Glantz



SECTION 7


Atherosclerosis and Coronary Heart Disease


32.Atherothrombosis: Disease Burden, Activity,


and Vulnerability871


Erling Falk and Valentin Fuster


33.Coronary Thrombosis: Local


and Systemic Factors880


Juan Jose Badimon, Borja Ibanez, Valentin Fuster, and Lina Badimon


34.Coronary Blood Flow and Myocardial


Ischemia893


K. Lance Gould, Henry Gewirtz, and Jagat Narula


35.Nonobstructive Atherosclerotic and Nonatherosclerotic Coronary


Heart Disease923


David E. Winchester and Carl J. Pepine


36.Definitions of Acute Coronary Syndromes946


Usman Baber, David Holmes, Jonathan Halperin, and Valentin Fuster


37.Pathology of Myocardial Infarction


and Sudden Death954


Maria E. Romero, Rodrigo Fernandez-Jimenez, Elena Ladich, Valentin Fuster, Borja Ibanez, and Renu Virmani


38.Molecular and Cellular Mechanisms


of Myocardial Ischemia/Reperfusion Injury977


Borja Ibanez, Gerd Heusch, David García-Dorado, Valentin Fuster, and Derek Yellon


39.Evaluation and Management of Non-ST-Segment Elevation


Myocardial Infarction995


David J. Moliterno and James L. Januzzi, Jr.


40.ST-Segment Elevation Myocardial Infarction ... 1017


Manesh R. Patel, Mandeep Singh, Bernard J. Gersh, and William O'Neill


41.Antiplatelet and Anticoagulant Therapy


in Acute Coronary Syndromes1055


Dominick J. Angiolillo, Gregory R. Giugliano, Daniel I. Simon, and Roxana Mehran


42.Percutaneous Coronary Interventions in Acute Myocardial Infarction


and Acute Coronary Syndromes1109


William O'Neill, Cindy Grines, and George Dangas


43.The Evaluation and Management


of Stable Ischemic Heart Disease1132


Bradley A. Maron, Bernard J. Gersh, and Patrick T. O'Gara


44.Coronary Artery Bypass Grafting


and Percutaneous Interventions in Stable


Ischemic Heart Disease1160


Michael E. Farkouh, Samin K. Sharma, Matthew I. Tomey, John Puskas,


and Valentin Fuster


45.Rehabilitation of the Patient with Coronary


Heart Disease1173


Mary Ann McLaughlin



Contentsvii


SECTION 8


Valvular Heart Disease


46.Acute Rheumatic Fever1187


Liesl Zühlke, Jagat Narula, and Jonathan R. Carapetis


47.


Blase A. Carabello and Rebecca T. Hahn


48.Degenerative Mitral Valve Disease1215


Javier G. Castillo, David H. Adams, Blasé A. Carabello, and Partho P. Sengupta


49.Ischemic Mitral Regurgitation1238


John D. Groarke, Blasé A. Carabello, and Patrick T. O'Gara


50.Mitral Stenosis1248


Vinay K. Bahl, Ravi S. Math, and Blasé A. Carabello


51.Tricuspid and Pulmonary Valve Disease1260


Joanna Y. Chikwe and Javier G. Castillo


52.Prosthetic Heart Valves1277


Joanna Chikwe and Javier G. Castillo


53.Antithrombotic Therapy for Valvular


Heart Disease1300


Vinay K. Bahl and Ravi S. Math


54.Management of Mixed Valvular


Heart Disease1310


Blasé A. Carabello



Volume Two


SECTION 9


Congenital Heart Disease


55.Mendelian Basis of Congenital and Other Cardiovascular Diseases1319


Ali J. Marian, Ramon Brugada, and Robert Roberts


56.Congenital Heart Disease in Adolescents


and Adults1363


Jeannette P. Lin, Jamil A. Aboulhosn, and John S. Child



SECTION 10


Myocardial, Pericardial, and Endocardial Diseases


57.Classification of Cardiomyopathies1397


Jagat Narula, Barry J. Maron, Navneet Narula, and Eloisa Arbustini


58.Dilated Cardiomyopathy1408


Eloisa Arbustini, Alessandra Serio, Valentina Favalli,


G.William Dec, and Jagat Narula


59.Hypertrophic Cardiomyopathies1443


Luís R. Lopes and Perry M. Elliott


60.Left Ventricular Noncompaction1465


Eloisa Arbustini, Alessandra Serio, Valentina Favalli, Nupoor Narula, and Maurizia Grasso


61.Restrictive Heart Diseases1482


Eloisa Arbustini, Alessandra Serio, Valentina Favalli,


G.William Dec, Giovanni Palladini, and Jagat Narula


62.Arrhythmogenic Cardiomyopathy1509


Srinivas R. Dukkipati, Peter J. Mohler, Lorenzo Paolo Giuliani, Valentina Favalli, Jagat Narula, and Eloisa Arbustini


63.Myocarditis1528


Eloisa Arbustini, Manuela Agozzino, Valentina Favalli, and Jagat Narula


64.The Athlete and the Cardiovascular


System1561


N. A. Mark Estes III, Mark S. Link, and Barry J. Maron


65.Cardiovascular Disease in the Elderly: Pathophysiology and Clinical


Implications1571


Joshua M. Stolker, Dae H. Kim, and Michael W. Rich


66.Pericardial Diseases1594


William R. Miranda, Massimo Imazio, Kevin L. Greason, John M. Stulak, and Jae K. Oh


67. Infective Endocarditis ....................... 1621


Joseph S. Alpert and Stephen A. Klotz



SECTION 11


Heart Failure


68.Pathophysiology of Heart Failure.............. 1651


Hanna K. Gaggin and G. William Dec


69.The Epidemiology of Heart Failure ............ 1674


Deepak K. Gupta, Charlotte Andersson, Ramachandran S. Vasan, and Thomas J. Wang


70.The Diagnosis and Management of


Chronic Heart Failure ....................... 1690


Tariq Ahmad, Javed Butler, and Barry Borlaug


71.Evaluation and Management of Acute


Heart Failure ............................... 1726


Michelle Weisfelner Bloom, Robert T. Cole, and Javed Butler



viiiContents


72. Cardiac Transplantation ..................... 1746


Michelle M. Kittleson, Jignesh K. Patel, and Jon A. Kobashigawa


73. Mechanically Assisted Circulation. . . . . . . . . . . . . 1768


Joseph G. Rogers, Chetan B. Patel, and Carmelo A. Milano



SECTION 12


Cardiopulmonary Disease


74. Pulmonary Hypertension .................... 1785


Lewis J. Rubin


75. Pulmonary Embolism ....................... 1809


Rodrigo Fernandez-Jimenez, Victor Tapson, Valentin Fuster, and Borja Ibanez


76.Cor Pulmonale: The Heart in Parenchymal


Lung Disease............................... 1835


Ori Ben-Yehuda


77.Sleep-Disordered Breathing and Cardiac


Disease .................................... 1841


Martin R. Cowie



SECTION 13


Rhythm and Conduction Disorders


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Product Description


Contributorsxi


Prefacexxv


Abbreviationsxxvii



Volume One


SECTION 1


Cardiovascular Disease: Past, Present, and Future


1.A History of the Cardiac Diseases, and


the Development of Cardiovascular Medicine


as a Specialty3


Robert A. Harrington, Mark E. Silverman, and Charles F. Wooley


2.The Global Burden of Cardiovascular Diseases19


Catherine P. Benziger, Andrew E. Moran, and Gregory A. Roth


3.Assessing and Improving the Quality of Care


in Cardiovascular Medicine52


Yashashwi Pokharel and John A. Spertus



SECTION 2


Foundations of Cardiovascular Medicine


4.Functional Anatomy of the Heart67


Joseph F. Malouf, Joseph J. Maleszewski, A. Jamil Tajik, and James B. Seward


5.Normal Physiology of the


Cardiovascular System101


Rodrigo Fernandez-Jimenez, Brian D. Hoit, Richard A. Walsh, Valentin Fuster, and Borja Ibanez


6.Molecular and Cellular Biology of the Heart125


Roger J. Hajjar, Kiyotake Ishikawa, and Thomas Thum


7.Biology of the Vessel Wall144


Hillary Johnston-Cox, Valentin Fuster, and Jason C. Kovacic


8.Molecular and Cellular Development


of the Heart161


Miguel Torres and Silvia Martín-Puig


9.Genetic Basis of Cardiovascular Disease174


Eloisa Arbustini, Valentina Favalli, Nupoor Narula, Eliana Disabella, and Maurizia Grasso


v


10.Stem Cells and the Cardiovascular System205


Karim Sallam and Joseph C. Wu



SECTION 3


Evaluation of the Patient


11.The History, Physical Examination, and


Cardiac Auscultation225


William R. Miranda and Rick A. Nishimura


12.Surface Electrocardiography252


Antoni Bayés de Luna, Diego Goldwasser, Miquel Fiol, and Antoni Bayés-Genis


13.Electrocardiographic Exercise Testing318


Gregory S. Thomas and Myrvin H. Ellestad


14.Cardiac Radiography335


Geoffrey D. Rubin


15.Echocardiography353


Thomas H. Marwick, Anthony N. DeMaria, Daniel G. Blanchard, and William A. Zoghbi


16.Magnetic Resonance Imaging of the Heart433


W. Gregory Hundley, Christopher M. Kramer, and Javier Sanz


17.Computed Tomography of the Heart469


Amir Ahmadi, Jagat Narula, and Jonathon Leipsic


18.Nuclear Cardiology499


Daniel S. Berman, Rory Hachamovitch, Leslee J. Shaw, Sean W. Hayes, Piotr J. Slomka, Guido Germano,


and Jagat Narula


19.Positron Emission Tomography


in Heart Disease553


K. Lance Gould, Heinrich Schelbert, and Jagat Narula


20.Cardiac Catheterization, Cardiac Angiography, and Coronary Blood Flow and Pressure


Measurements606


Morton J. Kern and Arnold H. Seto


21.Coronary Intravascular Imaging657


Christos V. Bourantas, Yoshinobu Onuma, Renu Virmani, Jagat Narula, and Patrick W. Serruys


22.Magnetic Resonance Imaging


and Computed Tomography of the


Vascular System686


Marc R. Dweck, Michelle C. Williams, Prakash Krishnan, Valentin Fuster, Jagat Narula, and Zahi A. Fayad



viContents


SECTION 4


Systemic Arterial Hypertension


23.Epidemiology of Hypertension703


Nathan D. Wong and Stanley S. Franklin


24.Pathophysiology of Hypertension720


John E. Hall, Joey P. Granger, Daniel W. Jones, and Michael E. Hall


25.Diagnosis and Treatment of Hypertension751


Lawrence R. Krakoff



SECTION 5


Metabolic Disorders and Cardiovascular Disease


26.The Metabolic Syndrome767


Michael A. Via and Jeffrey I. Mechanick


27.Obesity and Cardiovascular Disease776


W. Timothy Garvey and Jeffrey I. Mechanick


28.Diabetes and Cardiovascular Disease789


Michael E. Farkouh, Elliot J. Rayfield, and Valentin Fuster


29.Hyperlipidemia817


Robert S. Rosenson and Scott M. Grundy



SECTION 6


Cigarette Smoking and Cardiovascular Diseases


30.Epidemiology of Smoking and Pathophysiology


of Cardiovascular Damage849


Sunil K. Agarwal, Petra Maslov, Jagat Narula, and Valentin Fuster


31.Preventing and Mitigating Smoking-Related


Heart Disease860


Sara Kalkhoran and Stanton Glantz



SECTION 7


Atherosclerosis and Coronary Heart Disease


32.Atherothrombosis: Disease Burden, Activity,


and Vulnerability871


Erling Falk and Valentin Fuster


33.Coronary Thrombosis: Local


and Systemic Factors880


Juan Jose Badimon, Borja Ibanez, Valentin Fuster, and Lina Badimon


34.Coronary Blood Flow and Myocardial


Ischemia893


K. Lance Gould, Henry Gewirtz, and Jagat Narula


35.Nonobstructive Atherosclerotic and Nonatherosclerotic Coronary


Heart Disease923


David E. Winchester and Carl J. Pepine


36.Definitions of Acute Coronary Syndromes946


Usman Baber, David Holmes, Jonathan Halperin, and Valentin Fuster


37.Pathology of Myocardial Infarction


and Sudden Death954


Maria E. Romero, Rodrigo Fernandez-Jimenez, Elena Ladich, Valentin Fuster, Borja Ibanez, and Renu Virmani


38.Molecular and Cellular Mechanisms


of Myocardial Ischemia/Reperfusion Injury977


Borja Ibanez, Gerd Heusch, David García-Dorado, Valentin Fuster, and Derek Yellon


39.Evaluation and Management of Non-ST-Segment Elevation


Myocardial Infarction995


David J. Moliterno and James L. Januzzi, Jr.


40.ST-Segment Elevation Myocardial Infarction ... 1017


Manesh R. Patel, Mandeep Singh, Bernard J. Gersh, and William O'Neill


41.Antiplatelet and Anticoagulant Therapy


in Acute Coronary Syndromes1055


Dominick J. Angiolillo, Gregory R. Giugliano, Daniel I. Simon, and Roxana Mehran


42.Percutaneous Coronary Interventions in Acute Myocardial Infarction


and Acute Coronary Syndromes1109


William O'Neill, Cindy Grines, and George Dangas


43.The Evaluation and Management


of Stable Ischemic Heart Disease1132


Bradley A. Maron, Bernard J. Gersh, and Patrick T. O'Gara


44.Coronary Artery Bypass Grafting


and Percutaneous Interventions in Stable


Ischemic Heart Disease1160


Michael E. Farkouh, Samin K. Sharma, Matthew I. Tomey, John Puskas,


and Valentin Fuster


45.Rehabilitation of the Patient with Coronary


Heart Disease1173


Mary Ann McLaughlin



Contentsvii


SECTION 8


Valvular Heart Disease


46.Acute Rheumatic Fever1187


Liesl Zühlke, Jagat Narula, and Jonathan R. Carapetis


47.


Blase A. Carabello and Rebecca T. Hahn


48.Degenerative Mitral Valve Disease1215


Javier G. Castillo, David H. Adams, Blasé A. Carabello, and Partho P. Sengupta


49.Ischemic Mitral Regurgitation1238


John D. Groarke, Blasé A. Carabello, and Patrick T. O'Gara


50.Mitral Stenosis1248


Vinay K. Bahl, Ravi S. Math, and Blasé A. Carabello


51.Tricuspid and Pulmonary Valve Disease1260


Joanna Y. Chikwe and Javier G. Castillo


52.Prosthetic Heart Valves1277


Joanna Chikwe and Javier G. Castillo


53.Antithrombotic Therapy for Valvular


Heart Disease1300


Vinay K. Bahl and Ravi S. Math


54.Management of Mixed Valvular


Heart Disease1310


Blasé A. Carabello



Volume Two


SECTION 9


Congenital Heart Disease


55.Mendelian Basis of Congenital and Other Cardiovascular Diseases1319


Ali J. Marian, Ramon Brugada, and Robert Roberts


56.Congenital Heart Disease in Adolescents


and Adults1363


Jeannette P. Lin, Jamil A. Aboulhosn, and John S. Child



SECTION 10


Myocardial, Pericardial, and Endocardial Diseases


57.Classification of Cardiomyopathies1397


Jagat Narula, Barry J. Maron, Navneet Narula, and Eloisa Arbustini


58.Dilated Cardiomyopathy1408


Eloisa Arbustini, Alessandra Serio, Valentina Favalli,


G.William Dec, and Jagat Narula


59.Hypertrophic Cardiomyopathies1443


Luís R. Lopes and Perry M. Elliott


60.Left Ventricular Noncompaction1465


Eloisa Arbustini, Alessandra Serio, Valentina Favalli, Nupoor Narula, and Maurizia Grasso


61.Restrictive Heart Diseases1482


Eloisa Arbustini, Alessandra Serio, Valentina Favalli,


G.William Dec, Giovanni Palladini, and Jagat Narula


62.Arrhythmogenic Cardiomyopathy1509


Srinivas R. Dukkipati, Peter J. Mohler, Lorenzo Paolo Giuliani, Valentina Favalli, Jagat Narula, and Eloisa Arbustini


63.Myocarditis1528


Eloisa Arbustini, Manuela Agozzino, Valentina Favalli, and Jagat Narula


64.The Athlete and the Cardiovascular


System1561


N. A. Mark Estes III, Mark S. Link, and Barry J. Maron


65.Cardiovascular Disease in the Elderly: Pathophysiology and Clinical


Implications1571


Joshua M. Stolker, Dae H. Kim, and Michael W. Rich


66.Pericardial Diseases1594


William R. Miranda, Massimo Imazio, Kevin L. Greason, John M. Stulak, and Jae K. Oh


67. Infective Endocarditis ....................... 1621


Joseph S. Alpert and Stephen A. Klotz



SECTION 11


Heart Failure


68.Pathophysiology of Heart Failure.............. 1651


Hanna K. Gaggin and G. William Dec


69.The Epidemiology of Heart Failure ............ 1674


Deepak K. Gupta, Charlotte Andersson, Ramachandran S. Vasan, and Thomas J. Wang


70.The Diagnosis and Management of


Chronic Heart Failure ....................... 1690


Tariq Ahmad, Javed Butler, and Barry Borlaug


71.Evaluation and Management of Acute


Heart Failure ............................... 1726


Michelle Weisfelner Bloom, Robert T. Cole, and Javed Butler



viiiContents


72. Cardiac Transplantation ..................... 1746


Michelle M. Kittleson, Jignesh K. Patel, and Jon A. Kobashigawa


73. Mechanically Assisted Circulation. . . . . . . . . . . . . 1768


Joseph G. Rogers, Chetan B. Patel, and Carmelo A. Milano



SECTION 12


Cardiopulmonary Disease


74. Pulmonary Hypertension .................... 1785


Lewis J. Rubin


75. Pulmonary Embolism ....................... 1809


Rodrigo Fernandez-Jimenez, Victor Tapson, Valentin Fuster, and Borja Ibanez


76.Cor Pulmonale: The Heart in Parenchymal


Lung Disease............................... 1835


Ori Ben-Yehuda


77.Sleep-Disordered Breathing and Cardiac


Disease .................................... 1841


Martin R. Cowie



SECTION 13


Rhythm and Conduction Disorders


Show more
Product Details
EAN
9780071843249
ISBN
0071843248
Other Information
1690 Illustrations, unspecified
Dimensions
28.2 x 22.6 x 9.4 centimeters (5.36 kg)

Table of Contents

Contributorsxi

Prefacexxv

Abbreviationsxxvii


Volume One

SECTION 1

Cardiovascular Disease: Past, Present, and Future

1.A History of the Cardiac Diseases, and

the Development of Cardiovascular Medicine

as a Specialty3

Robert A. Harrington, Mark E. Silverman, and Charles F. Wooley

2.The Global Burden of Cardiovascular Diseases19

Catherine P. Benziger, Andrew E. Moran, and Gregory A. Roth

3.Assessing and Improving the Quality of Care

in Cardiovascular Medicine52

Yashashwi Pokharel and John A. Spertus


SECTION 2

Foundations of Cardiovascular Medicine

4.Functional Anatomy of the Heart67

Joseph F. Malouf, Joseph J. Maleszewski, A. Jamil Tajik, and James B. Seward

5.Normal Physiology of the

Cardiovascular System101

Rodrigo Fernandez-Jimenez, Brian D. Hoit, Richard A. Walsh, Valentin Fuster, and Borja Ibanez

6.Molecular and Cellular Biology of the Heart125

Roger J. Hajjar, Kiyotake Ishikawa, and Thomas Thum

7.Biology of the Vessel Wall144

Hillary Johnston-Cox, Valentin Fuster, and Jason C. Kovacic

8.Molecular and Cellular Development

of the Heart161

Miguel Torres and Silvia Martín-Puig

9.Genetic Basis of Cardiovascular Disease174

Eloisa Arbustini, Valentina Favalli, Nupoor Narula, Eliana Disabella, and Maurizia Grasso

v

10.Stem Cells and the Cardiovascular System205

Karim Sallam and Joseph C. Wu


SECTION 3

Evaluation of the Patient

11.The History, Physical Examination, and

Cardiac Auscultation225

William R. Miranda and Rick A. Nishimura

12.Surface Electrocardiography252

Antoni Bayés de Luna, Diego Goldwasser, Miquel Fiol, and Antoni Bayés-Genis

13.Electrocardiographic Exercise Testing318

Gregory S. Thomas and Myrvin H. Ellestad

14.Cardiac Radiography335

Geoffrey D. Rubin

15.Echocardiography353

Thomas H. Marwick, Anthony N. DeMaria, Daniel G. Blanchard, and William A. Zoghbi

16.Magnetic Resonance Imaging of the Heart433

W. Gregory Hundley, Christopher M. Kramer, and Javier Sanz

17.Computed Tomography of the Heart469

Amir Ahmadi, Jagat Narula, and Jonathon Leipsic

18.Nuclear Cardiology499

Daniel S. Berman, Rory Hachamovitch, Leslee J. Shaw, Sean W. Hayes, Piotr J. Slomka, Guido Germano,

and Jagat Narula

19.Positron Emission Tomography

in Heart Disease553

K. Lance Gould, Heinrich Schelbert, and Jagat Narula

20.Cardiac Catheterization, Cardiac Angiography, and Coronary Blood Flow and Pressure

Measurements606

Morton J. Kern and Arnold H. Seto

21.Coronary Intravascular Imaging657

Christos V. Bourantas, Yoshinobu Onuma, Renu Virmani, Jagat Narula, and Patrick W. Serruys

22.Magnetic Resonance Imaging

and Computed Tomography of the

Vascular System686

Marc R. Dweck, Michelle C. Williams, Prakash Krishnan, Valentin Fuster, Jagat Narula, and Zahi A. Fayad

 

viContents

SECTION 4

Systemic Arterial Hypertension

23.Epidemiology of Hypertension703

Nathan D. Wong and Stanley S. Franklin

24.Pathophysiology of Hypertension720

John E. Hall, Joey P. Granger, Daniel W. Jones, and Michael E. Hall

25.Diagnosis and Treatment of Hypertension751

Lawrence R. Krakoff


SECTION 5

Metabolic Disorders and Cardiovascular Disease

26.The Metabolic Syndrome767

Michael A. Via and Jeffrey I. Mechanick

27.Obesity and Cardiovascular Disease776

W. Timothy Garvey and Jeffrey I. Mechanick

28.Diabetes and Cardiovascular Disease789

Michael E. Farkouh, Elliot J. Rayfield, and Valentin Fuster

29.Hyperlipidemia817

Robert S. Rosenson and Scott M. Grundy


SECTION 6

Cigarette Smoking and Cardiovascular Diseases

30.Epidemiology of Smoking and Pathophysiology

of Cardiovascular Damage849

Sunil K. Agarwal, Petra Maslov, Jagat Narula, and Valentin Fuster

31.Preventing and Mitigating Smoking-Related

Heart Disease860

Sara Kalkhoran and Stanton Glantz


SECTION 7

Atherosclerosis and Coronary Heart Disease

32.Atherothrombosis: Disease Burden, Activity,

and Vulnerability871

Erling Falk and Valentin Fuster

33.Coronary Thrombosis: Local

and Systemic Factors880

Juan Jose Badimon, Borja Ibanez, Valentin Fuster, and Lina Badimon

34.Coronary Blood Flow and Myocardial

Ischemia893

K. Lance Gould, Henry Gewirtz, and Jagat Narula

35.Nonobstructive Atherosclerotic and Nonatherosclerotic Coronary

Heart Disease923

David E. Winchester and Carl J. Pepine

36.Definitions of Acute Coronary Syndromes946

Usman Baber, David Holmes, Jonathan Halperin, and Valentin Fuster

37.Pathology of Myocardial Infarction

and Sudden Death954

Maria E. Romero, Rodrigo Fernandez-Jimenez, Elena Ladich, Valentin Fuster, Borja Ibanez, and Renu Virmani

38.Molecular and Cellular Mechanisms

of Myocardial Ischemia/Reperfusion Injury977

Borja Ibanez, Gerd Heusch, David García-Dorado, Valentin Fuster, and Derek Yellon

39.Evaluation and Management of Non–ST-Segment Elevation

Myocardial Infarction995

David J. Moliterno and James L. Januzzi, Jr.

40.ST-Segment Elevation Myocardial Infarction  ... 1017

Manesh R. Patel, Mandeep Singh, Bernard J. Gersh, and William O’Neill

41.Antiplatelet and Anticoagulant Therapy

in Acute Coronary Syndromes1055

Dominick J. Angiolillo, Gregory R. Giugliano, Daniel I. Simon, and Roxana Mehran

42.Percutaneous Coronary Interventions in Acute Myocardial Infarction

and Acute Coronary Syndromes1109

William O’Neill, Cindy Grines, and George Dangas

43.The Evaluation and Management

of Stable Ischemic Heart Disease1132

Bradley A. Maron, Bernard J. Gersh, and Patrick T. O’Gara

44.Coronary Artery Bypass Grafting

and Percutaneous Interventions in Stable

Ischemic Heart Disease1160

Michael E. Farkouh, Samin K. Sharma, Matthew I. Tomey, John Puskas,

and Valentin Fuster

45.Rehabilitation of the Patient with Coronary

Heart Disease1173

Mary Ann McLaughlin

 

Contentsvii

SECTION 8

Valvular Heart Disease

46.Acute Rheumatic Fever1187

Liesl Zühlke, Jagat Narula, and Jonathan R. Carapetis

47.Aortic Valve Disease1196

Blase A. Carabello and Rebecca T. Hahn

48.Degenerative Mitral Valve Disease1215

Javier G. Castillo, David H. Adams, Blasé A. Carabello, and Partho P. Sengupta

49.Ischemic Mitral Regurgitation1238

John D. Groarke, Blasé A. Carabello, and Patrick T. O’Gara

50.Mitral Stenosis1248

Vinay K. Bahl, Ravi S. Math, and Blasé A. Carabello

51.Tricuspid and Pulmonary Valve Disease1260

Joanna Y. Chikwe and Javier G. Castillo

52.Prosthetic Heart Valves1277

Joanna Chikwe and Javier G. Castillo

53.Antithrombotic Therapy for Valvular

Heart Disease1300

Vinay K. Bahl and Ravi S. Math

54.Management of Mixed Valvular

Heart Disease1310

Blasé A. Carabello


Volume Two

SECTION 9

Congenital Heart Disease

55.Mendelian Basis of Congenital and Other Cardiovascular Diseases1319

Ali J. Marian, Ramon Brugada, and Robert Roberts

56.Congenital Heart Disease in Adolescents

and Adults1363

Jeannette P. Lin, Jamil A. Aboulhosn, and John S. Child


SECTION 10

Myocardial, Pericardial, and Endocardial Diseases

57.Classification of Cardiomyopathies1397

Jagat Narula, Barry J. Maron, Navneet Narula, and Eloisa Arbustini

58.Dilated Cardiomyopathy1408

Eloisa Arbustini, Alessandra Serio, Valentina Favalli,

G.William Dec, and Jagat Narula

59.Hypertrophic Cardiomyopathies1443

Luís R. Lopes and Perry M. Elliott

60.Left Ventricular Noncompaction1465

Eloisa Arbustini, Alessandra Serio, Valentina Favalli, Nupoor Narula, and Maurizia Grasso

61.Restrictive Heart Diseases1482

Eloisa Arbustini, Alessandra Serio, Valentina Favalli,

G.William Dec, Giovanni Palladini, and Jagat Narula

62.Arrhythmogenic Cardiomyopathy1509

Srinivas R. Dukkipati, Peter J. Mohler, Lorenzo Paolo Giuliani, Valentina Favalli, Jagat Narula, and Eloisa Arbustini

63.Myocarditis1528

Eloisa Arbustini, Manuela Agozzino, Valentina Favalli, and Jagat Narula

64.The Athlete and the Cardiovascular

System1561

N. A. Mark Estes III, Mark S. Link, and Barry J. Maron

65.Cardiovascular Disease in the Elderly: Pathophysiology and Clinical

Implications1571

Joshua M. Stolker, Dae H. Kim, and Michael W. Rich

66.Pericardial Diseases1594

William R. Miranda, Massimo Imazio, Kevin L. Greason, John M. Stulak, and Jae K. Oh

67.   Infective Endocarditis ....................... 1621

Joseph S. Alpert and Stephen A. Klotz


SECTION 11

Heart Failure

68.Pathophysiology of Heart Failure.............. 1651

Hanna K. Gaggin and G. William Dec

69.The Epidemiology of Heart Failure ............ 1674

Deepak K. Gupta, Charlotte Andersson, Ramachandran S. Vasan, and Thomas J. Wang

70.The Diagnosis and Management of

Chronic Heart Failure ....................... 1690

Tariq Ahmad, Javed Butler, and Barry Borlaug

71.Evaluation and Management of Acute

Heart Failure ...............................  1726

Michelle Weisfelner Bloom, Robert T. Cole, and Javed Butler

 

viiiContents

72.   Cardiac Transplantation ..................... 1746

Michelle M. Kittleson, Jignesh K. Patel, and Jon A. Kobashigawa

73.  Mechanically Assisted Circulation. . . . . . . . . . . . . 1768

Joseph G. Rogers, Chetan B. Patel, and Carmelo A. Milano


SECTION 12

Cardiopulmonary Disease

74.   Pulmonary Hypertension .................... 1785

Lewis J. Rubin

75.   Pulmonary Embolism ....................... 1809

Rodrigo Fernandez-Jimenez, Victor Tapson, Valentin Fuster, and Borja Ibanez

76.Cor Pulmonale: The Heart in Parenchymal

Lung Disease...............................  1835

Ori Ben-Yehuda

77.Sleep-Disordered Breathing and Cardiac

Disease ....................................  1841

Martin R. Cowie


SECTION 13

Rhythm and Conduction Disorders

78.Electrophysiologic Anatomy  ................. 1865

Jonathan P. Piccini, Siew Yen Ho, and Anton E. Becker

79.Mechanisms of Cardiac Arrhythmias

and Conduction Disturbances ................ 1881

Peng-Sheng Chen and Charles Antzelevitch

80.Genetics of Channelopathies and Clinical  Implications  ...............................  1910

Silvia G. Priori and Carlo Napolitano

81.Approach to the Patient with

Cardiac Arrhythmias........................  1923

Sanjiv M. Narayan and David E. Krummen

82.Invasive Diagnostic Electrophysiology ......... 1938

Dinesh Sharma and Srinivas R. Dukkipati

83.Atrial Fibrillation, Atrial Flutter,

and Atrial Tachycardia....................... 1950

Eric N. Prystowsky, Jonathan Halperin, and Peter Kowey

84.Supraventricular Tachycardia: Atrial Tachycardia, Atrioventricular Nodal Reentry,

and Wolff-Parkinson-White Syndrome  ........ 1967

Hugh Calkins

85.   Ventricular Arrhythmias.....................  1983

Jason S. Bradfield, Noel G. Boyle, and Kalyanam Shivkumar

86.   Bradyarrhythmias  .......................... 2006

Pugazhendhi Vijayaraman and Kenneth A. Ellenbogen

87.   Antiarrhythmic Drugs.......................  2029

Joshua M. Arkin, Colleen Hanley, Gan-Xin Yan, and Peter R. Kowey

88.Catheter-Ablative Techniques  ................ 2047

Amit Noheria, Abhishek J. Deshmukh, Christopher McLeod, and Samuel J. Asirvatham

89.Pacemakers and Defibrillators ................ 2066

Gaurav A. Upadhyay and Jagmeet P. Singh

90.Diagnosis and Management of Syncope ........ 2098

Blair P. Grubb

91.   Sudden Cardiac Death....................... 2113

Jonathan W. Waks and Mark E. Josephson

92.   Cardiopulmonary and Cardiocerebral

Resuscitation  ..............................  2144

Eyal Herzog, Lee Herzog, and Emad Aziz


SECTION 14

Diseases of the Great Vessels and Peripheral Vessels

93.   Diseases of the Aorta ........................ 2157

John A. Elefteriades, Jeffrey W. Olin,   Jonathan L. Halperin, and Bulat A. Ziganshin

94.  Cerebrovascular Disease and Neurologic Manifestations of Heart Disease............... 2195

Megan C. Leary, Jeffrey S. Veluz, and Louis R. Caplan

95.   Carotid Artery Stenting...................... 2222

Sriram Iyer, Gary Roubin, and Jeffrey W. Olin

96.Diagnosis and Management of Diseases of the Peripheral Arteries..........................  2248

Kevin P. Cohoon, Paul W. Wennberg, and Thom W. Rooke

97.Diagnosis and Management of Diseases of the Peripheral Venous System.................... 2261

Daniella Kadian-Dodov and Jeffrey W. Olin


SECTION 15

Miscellaneous Conditions and Cardiovascular Disease

98.Perioperative Evaluation for

Noncardiac Surgery ......................... 2275

Daniel Alyesh and Kim Eagle

 

Contentsix

 99.Anesthesia and the Patient with

Cardiovascular Disease . . . . . . . . . . . . . . . . . . . . . .  2284

David L. Reich, Alexander J. C. Mittnacht, and Joel A. Kaplan

100.Rheumatologic Diseases and the

Cardiovascular System   . . . . . . . . . . . . . . . . . . . . . .  2293

Parisa Azizad-Pinto and Victor F. Tapson

101.The Diagnosis and Management of Cardiovascular Diseases in Patients

with Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  2308

Gagan Sahni, Tiziano Scarabelli, and Edward T. H. Yeh

102.HIV/AIDS and the Cardiovascular

System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  2328

William Lewis and Peter F. Currie

103.  Heart Disease in Pregnancy   . . . . . . . . . . . . . . . . . .  2345

Dan G. Halpern, Amy Sarma, Katherine E. Economy, and Anne Marie Valente

104.  Traumatic Heart Disease . . . . . . . . . . . . . . . . . . . . . 2364

T. Bruce Ferguson, Jr.

105. The Kidney in Heart Disease   . . . . . . . . . . . . . . . . . 2369

Bjorn Redfors, Rushad Dordi, and Ori Ben-Yehuda

106.Exercise in Health and Cardiovascular

Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  2388

Gerald F. Fletcher, Thomas R. Flipse, and Robert E. Safford

 

SECTION 16

Populations and Social Determinants of Cardiovascular  Disease

107.Social Determinants of Cardiovascular

Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2401

Holly G. Atkinson

108.Women and Ischemic Heart Disease:

An Evolving Saga . . . . . . . . . . . . . . . . . . . . . . . . . . .  2414

Leslee J. Shaw, Pamela Charney, and Nanette K. Wenger

109.Race, Ethnicity, and Cardiovascular Disease     .   . . .  2434

George A. Mensah and Patrice Desvigne-Nickens

110.  Environment and Heart Disease   . . . . . . . . . . . . . .  2449

Philip J. Landrigan and Kimberly Morland

111.Behavioral     Cardiology:     Epidemiology,   Pathophysiology, and Clinical Management      .   .   .   . 2459

Alan Rozanski

112.Economics and Cost-Effectiveness

in Cardiology   . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  2472

Daniel B. Mark


Index     . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .  I1–I78

 














 




     



 






 

About the Author

Valentin Fuster, MD, PhD, MACC, FAHA (New York, NY)  serves The Mount Sinai Medical Hospital as Physician-in-Chief, as well as Director of Mount Sinai Heart, the Zena and Michael A. Wiener Cardiovascular Institute and the Marie-Josée and Henry R. Kravis Center for Cardiovascular Health. He is also the Richard Gorlin, MD/Heart Research Foundation Professor, Icahn School of Medicine at Mount Sinai.  Dr. Fuster was the President of Science and is now the General Director of the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) in Madrid, Spain and also and Chairman of the SHE Foundation (Science for Health and Education).

 

The innumerable positions he has held include those of President of the American Heart Association, President of the World Heart Federation, member of the Institute of Medicine of the US National Academy of Sciences (where he chaired the Committee for the document on "promotion of cardiovascular health worldwide), member of the US National Heart, Lung and Blood Institute and President of the Training Program of the American College of Cardiology.

 

Robert A. Harrington, MD, FACC, FAHA (Stanford, CA) is an interventional cardiologist and Professor of Medicine and Chairman of the Department of Medicine at Stanford University. He was previously the Richard Sean Stack, MD, Distinguished Professor and the Director of the Duke Clinical Research Institute (DCRI) at Duke University. His research interests include evaluating antithrombotic therapies to treat acute ischemic heart disease and to minimize the acute complications of percutaneous coronary procedures; studying the mechanism of disease of the acute coronary syndromes; understanding the issue of risk stratification in the care of patients with acute ischemic coronary syndromes; building local, national, and international collaborations for the efficient conduct of innovative clinical research; and trying to better understand and improve upon the methodology of clinical trials.Jagat Narula, MD, PhD, MACC (New York, NY) is Professor of Medicine and Philip J. and Harriet L. Goodhart Chair in Cardiology, and the Director of Cardiovascular Imaging Program in Mount Sinai’s Zena and Michael A. Wiener Cardiovascular Institute and the Marie-Josée and Henry R. Kravis Center for Cardiovascular Health. He is the Associate Dean for Global Health at the Icahn School of Medicine at Mount Sinai. Dr Narula has the unique distinction of being able to combine molecular and subcellular pathology and imaging.

 

Zubin J. Eapen, MD (Durham, NC) Assistant Professor of Medicine, Duke University Medical Center,   Medical Director of the Duke Heart Failure Same Day Access Clinic, Department of Medicine Director of Education IT Innovations, and Department of Medicine Director of Clinical Improvement. He is also a member of Duke Clinical Research Institute Health Services Research Group and Assistant Faculty Director for the Center for Educational Excellence. Dr. Eapen obtained his medical degree and completed his residency and Cardiology Fellowship at Duke University. He serves as Electronic Media Editor for JACC: Heart Failure, Associate Editor for American Heart Journal, and Editor for the 14th edition of Hurst’s the Heart. His particular interests include improving care coordination, disease management, and quality of care using digital health tools.

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