This book provides a comprehensive methodology for automated design, test and diagnosis, and use of robust, low-cost, and manufacturable digital microfluidic systems. It focuses on the development of a comprehensive CAD optimization framework for digital microfluidic biochips that unifies different design problems. With the increase in system complexity and integration levels, biochip designers can utilize the design methods described in this book to evaluate different design alternatives, and carry out design-space exploration to obtain the best design point.

Introduction.- Cross-Contamination Avoidance for Droplet Routing.- Synchronization of Concurrently-Implemented Fluidic Operations in Pin-Constrained Biochips.- Optimization of Droplet Routing and Control-Pin Mapping to Electrodes.- Built-In Self Test and Diagnosis.- On-Line Testing and Test Generation.- Integrated Control-Path Design and Error Recovery.- Conclusions.