This research develops the design of several components and/or systems for an experimental space-based chromotomographic hyperspectral imager that is being built by the Air Force Institute of Technology. The design work included three separate topics. The first topic was the development of a structure utilizing finite element analysis and eigenvalue modal analysis for the ground-based version of the chromotomographic experiment. The ground-based experiment was performed as a risk mitigation measure for the space-based experiment. The second topic included a design review of a contractor's proposed off-axis mersenne telescope for the space-based chromotomographic hyperspectral imager. The third topic addressed was a trade study of on-orbit focus, alignment and calibration schemes for the space-based version of the chromotomography experiment.