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Chemical and Structural ­Approaches to Rational Drug­ Design
Pharmacology & Toxicology S.
By David B. Weiner (Edited by), William V. Williams (Edited by)

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Format
Hardback, 290 pages
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Paperback : £54.68

Published
United States, 28 November 1994

This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.


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£242
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£400.00
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Product Description

This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.

Product Details
EAN
9780849378188
ISBN
0849378184
Other Information
44 black & white tables, 18 black & white halftones
Dimensions
26.5 x 17.8 x 1.9 centimeters (0.72 kg)

Table of Contents

Section I: Chemical Approaches to Rational Drug Design 1. Design, Synthesis and Antitumor Activity of an Inhibitor of Ribonucleotide Reductase 2. The Development of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors 3. The Development of Potent Angiotensin II Receptor Antagonists Using a Novel Peptide Pharmacophore Model 4. Endothelin Structure and Development of Receptor Antagonists 5. Molecular Targeting Chemistry in Rational Drug Design Section II: Structural Approaches to Rational Drug Design 6. The Role of X-Ray Crystallography in Structure-Based Rational Drug Design 7. Biocomputational Approaches to Protein-Based Drug Design 8. Architecture and Design of Zinc Protein-Ligand Complexes 9. Design of Immunomodulatory Peptides Based on Active Site Structures

About the Author

Weiner, David B.; Williams, William V.

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