Advanced Topics in Forensic DNA Typing: Interpretation builds upon the previous two editions of John Butler's internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. Intended as a third-edition companion to the Fundamentals of Forensic DNA Typing volume published in 2010 and Advanced Topics in Forensic DNA Typing: Methodology published in 2012, this book contains 16 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field. Over 80 % of the content of this book is new compared to previous editions. * Provides forensic DNA analysts coverage of the crucial topic of DNA mixture interpretation and statistical analysis of DNA evidence* Worked mixture examples illustrate the impact of different statistical approaches for reporting results* Includes allele frequencies for 24 commonly used autosomal STR loci, the revised Quality Assurance Standards which went into effect September 2011
Advanced Topics in Forensic DNA Typing: Interpretation builds upon the previous two editions of John Butler's internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. Intended as a third-edition companion to the Fundamentals of Forensic DNA Typing volume published in 2010 and Advanced Topics in Forensic DNA Typing: Methodology published in 2012, this book contains 16 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field. Over 80 % of the content of this book is new compared to previous editions. * Provides forensic DNA analysts coverage of the crucial topic of DNA mixture interpretation and statistical analysis of DNA evidence* Worked mixture examples illustrate the impact of different statistical approaches for reporting results* Includes allele frequencies for 24 commonly used autosomal STR loci, the revised Quality Assurance Standards which went into effect September 2011
A comprehensive resource of DNA mixture interpretation and statistical analysis of DNA evidence, by the foremost expert in the field
Section 1: DATA INTERPRETATION
Chapter 1: Data Interpretation Overview
Chapter 2: Data, Models & Thresholds
Chapter 3: STR Alleles & Artifacts
Chapter 4: STR Genotypes
Chapter 5: STR Profiles
Chapter 6: DNA Mixtures
Chapter 7: Low-Level DNA & Complex Mixtures
Chapter 8: Troubleshooting Data Collection
Section 2: STATISTICAL INTERPRETATION
Chapter 9: Statistical Interpretation Overview
Chapter 10: STR Population Data Analysis
Chapter 11: DNA Profile Frequency Estimates
Chapter 12: DNA Mixture Statistics
Chapter 13: Coping with Missing Alleles
Chapter 14: Relationship Testing
Chapter 15: Lineage Marker Statistics
Chapter 16: Laboratory Reports: Communicating Results and
Conclusions
APPENDICES
Appendix 1: STR Allele Frequencies from U.S. Population Data
Appendix 2: NRC I and NRC II Recommendations
Appendix 3: DAB Recommendations on Statistics
Appendix 4: Worked mixture example (by Dr. Michael D. Coble)
John M. Butler is a NIST Fellow and Special Assistant to the Director for Forensic Science, Office of Special Programs, at the U.S. National Institute of Standards and Technology, in Gaithersburg, Maryland. Dr. Butler earned his PhD from the University of Virginia while doing DNA research in the FBI Laboratory's Forensic Science Research Unit. He has won numerous scientific awards, including being named Science Watch’s #1 world-wide high-impact author in legal medicine and forensic science over the last decade (July 2011). He has over 150 publications in this field and is a frequent presenter on the topic of DNA typing, and has authored four other DNA Typing books including Advanced Topics in Forensic DNA Typing: Methodology. For a detailed CV, visit http://www.cstl.nist.gov/strbase/butler.htm.
"As a communicator and researcher engaged forensic DNA
analyses, John Butler is at the pinnacle of his profession. As with
the previous two volumes in this series, Butler leaves no stone
unturned in the clarity of his A to Y coverage of forensic DNA
interpretation. This book is bound to find its way onto the
fingertips of practitioners, attorneys, and students." --Richard
Saferstein, Ph.D., Chief Forensic Scientist (Retired)
"…It is an excellent companion to his prior book on methodology,
providing important information on interpretation of results… The
book should prove valuable to all people involved in processing and
interpreting results used in forensic genetics and criminal
investigation." -- Bruce McCord, Ph.D., Professor, Florida
International University
"Advanced Topics in DNA Typing/Interpretation is Dr. John Butler’s
best book yet in his critically acclaimed series of DNA text
books..." --Stephen Patrick Hogan Adjunct Associate Professor of
Biological Science and Criminal Justice, State University of New
York at Albany
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